DARS and AIMP2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, biochemical, biochemical)
HPRD (two hybrid)

		DARS	AIMP2
Gene Name		aspartyl-tRNA synthetase	aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome	Nucleus Cytosol Membrane
	Molecular Function	Aminoacylase Activity Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Aspartyl-tRNA Aminoacylation Protein Complex Assembly Gene Expression	TRNA Aminoacylation For Protein Translation Apoptotic Process Negative Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Protein Ubiquitination Type II Pneumocyte Differentiation
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	Cytosolic tRNA aminoacylation tRNA Aminoacylation
Drugs		L-Aspartic Acid
Diseases
GWAS
Protein-Protein Interactions		3 interactors: AIMP2 EEF1A1 PIK3R3	48 interactors: ACTB AIMP1 APP BCAS2 BLOC1S4 BYSL C19orf57 CEP170P1 CHD3 DARS DARS2 DEAF1 DSN1 EPRS EPS8 FGB FHL3 FUBP1 GYS1 ICE1 KARS KDR KIAA1377 KLC2 LMO2 LMO3 LNX1 LUC7L2 MATR3 MCF2L MIS18A NDEL1 NECAB2 NGFRAP1 PARK2 PCMT1 PLEKHF2 PPP2R1A PRKAA2 PSME1 TANK TERF2IP TFIP11 TP53 TRAF2 TRMT2A ZC3H12A ZGPAT
Entrez ID		1615	7965
HPRD ID		04361	02915
Ensembl ID		ENSG00000115866	ENSG00000106305
Uniprot IDs		P14868	A8MU58 Q13155
PDB IDs		4J15	4DPG
Enriched GO Terms of Interacting Partners?			RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Component Assembly TRNA Aminoacylation For Protein Translation Axon Cargo Transport TRNA Aminoacylation Cell Cycle Process NcRNA Metabolic Process Mitotic Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Regulation Of Autophagy Mitotic Cell Cycle Apoptotic Process Platelet Aggregation Negative Regulation Of Reactive Oxygen Species Metabolic Process Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Mitochondrion Degradation Protein Complex Assembly Microtubule-based Transport Immune System Process Cell Death Death TRNA Metabolic Process Cellular Response To Organic Substance Cytoskeleton-dependent Intracellular Transport Blood Coagulation Cell Cycle Cellular Macromolecule Biosynthetic Process Hemostasis Positive Regulation Of Peptidase Activity Macromolecule Biosynthetic Process Cellular Process Cellular Amino Acid Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Proteolysis Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Cellular Metabolic Process Response To Wounding Regulation Of Signaling Regulation Of Cellular Ketone Metabolic Process
Tagcloud ?		adc antimicrotubule characterize characterizing compartments composed conjugate deconjugation disposition dm1 emtansine explain final half humanized integrates mechanistic modeling monkeys pharmacokinetics platform preclinical prior semi shorter transit translated trastuzumab ttmab	4x20 abl abrogated bbb c57 compacts dopaminergic e3 easily endothelium inno irreversible microvessel mitigated mptp nanomolar neurodegeneration neuroprotective nigra nitrative parkin pars pd pharmacokinetic striatum substantia th translated ubiquitously
Tagcloud (Difference) ?		adc antimicrotubule characterize characterizing compartments composed conjugate deconjugation disposition dm1 emtansine explain final half humanized integrates mechanistic modeling monkeys pharmacokinetics platform preclinical prior semi shorter transit trastuzumab ttmab	4x20 abl abrogated bbb c57 compacts dopaminergic e3 easily endothelium inno irreversible microvessel mitigated mptp nanomolar neurodegeneration neuroprotective nigra nitrative parkin pars pd pharmacokinetic striatum substantia th ubiquitously
Tagcloud (Intersection) ?		translated