CD55 and CD14

Number of citations of the paper that reports this interaction (PMID 11745332)
43

Data Source:
HPRD (in vitro)

		CD55	CD14
Gene Name		CD55 molecule, decay accelerating factor for complement (Cromer blood group)	CD14 molecule
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Endosome Membrane Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Virus Receptor Activity Protein Binding Lipid Binding	Lipopolysaccharide Binding Opsonin Receptor Activity Protein Binding Peptidoglycan Receptor Activity Lipoteichoic Acid Binding
	Biological Process	Complement Activation, Classical Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Virus Regulation Of Complement Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway CD4-positive, Alpha-beta T Cell Cytokine Production Innate Immune Response Respiratory Burst Negative Regulation Of Complement Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Heat Response To Magnesium Ion Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Response To Ethanol Positive Regulation Of Endocytosis Positive Regulation Of Cytokine Secretion Response To Electrical Stimulus Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Regulation of Complement cascade Complement cascade Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors) Innate Immune System	TRAF6 mediated induction of TAK1 complex IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling MyD88-independent cascade Toll Like Receptor TLR6:TLR2 Cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Transfer of LPS from LBP carrier to CD14 Toll Like Receptor 2 (TLR2) Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88:Mal cascade initiated on plasma membrane TRIF-mediated programmed cell death Innate Immune System
Drugs		Chloramphenicol
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CD14 CD97 CR1 FYN GPLD1 LCK	14 interactors: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 TLR2 TLR3 TLR4 TNFRSF1B
Entrez ID		1604	929
HPRD ID		00500	01151
Ensembl ID		ENSG00000196352	ENSG00000170458
Uniprot IDs		B1AP13 P08174	P08571
PDB IDs		1H03 1H04 1H2P 1H2Q 1M11 1NWV 1OJV 1OJW 1OJY 1OK1 1OK2 1OK3 1OK9 1UOT 1UPN 2C8I 2QZD 2QZF 2QZH 3IYP 3J24	4GLP
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Signaling Pathway Positive Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Complement Receptor Mediated Signaling Pathway Positive Regulation Of Immune System Process Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Cell Surface Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Innate Immune Response Positive Regulation Of Proteolysis Peptidyl-tyrosine Autophosphorylation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Metal Ion Response To Abiotic Stimulus Signal Transduction Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Inorganic Substance T Cell Costimulation Response To Peptide Regulation Of Defense Response To Virus Response To Drug Signaling Movement Of Cell Or Subcellular Component Cell Communication GPI Anchor Release Cellular Response To Triglyceride Positive Regulation Of Serine-type Endopeptidase Activity Cellular Response To Hormone Stimulus T Cell Receptor Signaling Pathway Response To Stress Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Ethanol Positive Regulation Of Endopeptidase Activity Cellular Response To Stimulus Antigen Receptor-mediated Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Complement Activation, Alternative Pathway Hematopoietic Stem Cell Migration To Bone Marrow Hematopoietic Stem Cell Migration Phosphatidylinositol-mediated Signaling Cellular Response To Organic Substance Positive Regulation Of Peptidase Activity	Regulation Of Tumor Necrosis Factor Production Toll-like Receptor Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Other Organism Response To Biotic Stimulus Macrophage Activation Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-6 Production Regulation Of Innate Immune Response Response To Bacterium Defense Response Regulation Of Inflammatory Response Positive Regulation Of Immune System Process Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Chemokine Production Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune Response Regulation Of Chemokine Production Positive Regulation Of Tumor Necrosis Factor Production Response To Stress Defense Response To Bacterium Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Inflammatory Response Detection Of Molecule Of Bacterial Origin Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Response To External Stimulus I-kappaB Phosphorylation Negative Regulation Of Cytokine Production Innate Immune Response Immune Response Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Inflammatory Response Regulation Of Cytokine Production Positive Regulation Of NF-kappaB Import Into Nucleus Immune System Process Regulation Of Protein Metabolic Process
Tagcloud ?		abc accelerating acinar apical cd46 cd59 cofactor complement connection decay ductal exocrine exocrinopathy gland glands immunoblotting immunoperoxidase inflamed interstitial labial protectin protecting regulators saliva salivary sjogren sp ss surfaces	1beta 1ra antiinflammatory bmmc ccf cd11b cd16 cd64 cd68 cd95 cholecalciferol explain granulocyte immature immunoassay methotrexate monoblastic monocytic mononuclear mtx oh p75 pbmc rheumatoid sorter stnfr supernatants u937 undifferentiated
Tagcloud (Difference) ?		abc accelerating acinar apical cd46 cd59 cofactor complement connection decay ductal exocrine exocrinopathy gland glands immunoblotting immunoperoxidase inflamed interstitial labial protectin protecting regulators saliva salivary sjogren sp ss surfaces	1beta 1ra antiinflammatory bmmc ccf cd11b cd16 cd64 cd68 cd95 cholecalciferol explain granulocyte immature immunoassay methotrexate monoblastic monocytic mononuclear mtx oh p75 pbmc rheumatoid sorter stnfr supernatants u937 undifferentiated
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