AMOT and LMO4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		AMOT	LMO4
Gene Name		angiomotin	LIM domain only 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Tight Junction COP9 Signalosome External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Lamellipodium Endocytic Vesicle	Transcription Factor Complex
	Molecular Function	Receptor Activity Protein Binding Angiostatin Binding	Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Zinc Ion Binding
	Biological Process	Vasculogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Chemotaxis Cell-cell Junction Assembly Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Regulation Of Cell Migration Negative Regulation Of GTPase Activity Cellular Protein Localization Hippo Signaling Positive Regulation Of Embryonic Development Cell Migration Involved In Gastrulation Negative Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Size Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly	Neural Tube Closure Ventricular Septum Development Transcription From RNA Polymerase II Promoter Ventral Spinal Cord Interneuron Differentiation Spinal Cord Motor Neuron Differentiation Spinal Cord Association Neuron Differentiation Negative Regulation Of Protein Complex Assembly Regulation Of Cell Fate Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Regulation Of Cell Activation
Pathways
Drugs
Diseases
GWAS			Response to TNF antagonist treatment ( 18615156) White blood cell types ( 21738478)
Protein-Protein Interactions		21 interactors: ACTA1 APP C1orf216 KRT15 KRT31 LATS1 LATS2 LMO4 LURAP1 MAGEA4 MAGI1 MAPK3 MED4 NEDD4 PIN1 PLG PPP2R4 SEPT1 SNAPC5 UNC119 WDYHV1	53 interactors: AES AMOT AMOTL2 BANP BRCA1 CALCOCO2 CCDC102B CEP170P1 CSNK2B DDB1 DEAF1 ERCC6L GABPB1 GADD45A GOLGA2 GRHL2 GSK3B ITSN1 KANK2 KIAA1958 KIF3B KPNA1 KRT15 KRT31 KRT40 LDB1 LDB2 MERTK MTA1 NFYC NHLH1 NONO PDE4DIP PITPNB PLK1 PPARG RBBP8 RBPMS RPS6KA6 SEC24D SMAD4 SMAD9 TCF21 TCF4 TFIP11 TINAGL1 TNFSF11 TP53BP2 TSEN15 VPS52 ZBTB43 ZNF397 ZNF675
Entrez ID		154796	8543
HPRD ID		02327	09122
Ensembl ID		ENSG00000126016	ENSG00000143013
Uniprot IDs		Q4VCS5	P61968
PDB IDs			2L4Z
Enriched GO Terms of Interacting Partners?		Tissue Development Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorylation Epidermis Development Cell Cycle Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Hippo Signaling Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Protein Kinase Activity Negative Regulation Of Phosphorylation Cell Division Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Platelet Activation Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process DNA-templated Transcription, Initiation Positive Regulation Of Metabolic Process Mitotic Spindle Organization In Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Apolipoprotein Binding Transmission Of Virus Development Involved In Symbiotic Interaction Neuromuscular Junction Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Neuron Death Regulation Of Sodium Ion Transport Epithelium Development Negative Regulation Of Signal Transduction Protein Peptidyl-prolyl Isomerization Platelet Degranulation Response To Abiotic Stimulus Intracellular Steroid Hormone Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation Synaptic Growth At Neuromuscular Junction Negative Regulation Of Caveolin-mediated Endocytosis Organ Development	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Tissue Development Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Multicellular Organismal Development Developmental Process Gene Expression Regulation Of Binding Regulation Of Gene Expression Anatomical Structure Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Epithelium Development Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Embryo Development Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Nucleocytoplasmic Transport Embryo Development Ending In Birth Or Egg Hatching Regulation Of Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Metabolic Process Biosynthetic Process Regulation Of DNA Methylation Cell Cycle Somatic Stem Cell Maintenance Regulation Of Protein Binding Anatomical Structure Morphogenesis
Tagcloud ?		actin alanine amotl2 amots angiomotin collectively consensus contain core dissociation endogenously exogenous filaments hippo hxrxxs lats1 lats2 mapping mediate members mimic negatively phospho promoted s175a s175d serine taz yap	arrays attenuated cisplatin cochlea cochlear collectively custom downstream esr1 facilitates immunoblots insights interactomes jak1 machinery mediating modulating modulation nitration otoprotective ototoxicity partners pivotal player relaying stat stat3 trolox wistar
Tagcloud (Difference) ?		actin alanine amotl2 amots angiomotin consensus contain core dissociation endogenously exogenous filaments hippo hxrxxs lats1 lats2 mapping mediate members mimic negatively phospho promoted s175a s175d serine taz yap	arrays attenuated cisplatin cochlea cochlear custom downstream esr1 facilitates immunoblots insights interactomes jak1 machinery mediating modulating modulation nitration otoprotective ototoxicity partners pivotal player relaying stat stat3 trolox wistar
Tagcloud (Intersection) ?		collectively