CTSL and ARSA

Number of citations of the paper that reports this interaction (PMID 11777924)
2

Data Source:
HPRD (in vitro)

		CTSL	ARSA
Gene Name		cathepsin L	arylsulfatase A
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Lysosome Endolysosome Lumen Lysosomal Lumen Extracellular Vesicular Exosome	Acrosomal Vesicle Extracellular Space Lysosome Endosome Endoplasmic Reticulum Lumen Integral Component Of Membrane Extrinsic Component Of External Side Of Plasma Membrane Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Histone Binding Proteoglycan Binding	Arylsulfatase Activity Cerebroside-sulfatase Activity Calcium Ion Binding Sulfuric Ester Hydrolase Activity
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Proteolysis Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus	Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Autophagy Binding Of Sperm To Zona Pellucida Central Nervous System Development Response To Nutrient Response To PH Response To Estrogen Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process Response To Ethanol Response To Methylmercury
Pathways		Collagen formation Collagen degradation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Trafficking and processing of endosomal TLR Toll-Like Receptors Cascades MHC class II antigen presentation Endosomal/Vacuolar pathway Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Adaptive Immune System Innate Immune System	Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism Post-translational protein modification The activation of arylsulfatases Gamma carboxylation, hypusine formation and arylsulfatase activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 PLAU PPP1CC RELB RXRA SERPINB13 SERPINB3 SGTA SLPI TG	7 interactors: BMPR2 CETN2 CLEC4G CTSL GAL3ST1 PPIC TRIP13
Entrez ID		1514	410
HPRD ID		00293	09617
Ensembl ID		ENSG00000135047
Uniprot IDs		P07711 Q9HBQ7	B4DVI5 P15289
PDB IDs		1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM	1AUK 1E1Z 1E2S 1E33 1E3C 1N2K 1N2L 2AIJ 2AIK
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Protein Processing Negative Regulation Of Endopeptidase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrolase Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Process Response To Stimulus Regulation Of Metabolic Process Protein Insertion Into ER Membrane Immune Response Regulation Of Apoptotic Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Cell Death Adaptive Immune Response Protein Insertion Into Membrane Positive Regulation Of Neutrophil Chemotaxis Immune System Process Positive Regulation Of Granulocyte Chemotaxis Regulation Of Cell Migration Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Regulation Of Cell Motility T Cell Mediated Immunity Regulation Of Granulocyte Chemotaxis Regulation Of Locomotion Cell Activation Positive Regulation Of Histone Methylation Regulation Of Cellular Component Movement Response To Abiotic Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Macrophage Migration Inhibitory Factor Signaling Pathway Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Endoplasmic Reticulum Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Histone Methylation Negative Regulation Of Blood Coagulation	Spermatogenesis Male Gamete Generation Gamete Generation Regulation Of Lung Blood Pressure Macrophage Apoptotic Process Galactosylceramide Biosynthetic Process Negative Regulation Of Chondrocyte Proliferation Sexual Reproduction Multicellular Organismal Reproductive Process Negative Regulation Of Vasoconstriction Multicellular Organism Reproduction Reproduction Myeloid Cell Apoptotic Process Positive Regulation Of Axon Extension Involved In Axon Guidance Inflammatory Cell Apoptotic Process Lymphatic Endothelial Cell Differentiation Single Organism Reproductive Process Cellular Response To Thyroid Hormone Stimulus Galactosylceramide Metabolic Process Lymphangiogenesis Reproductive Process Lymph Vessel Morphogenesis Female Meiosis I Glycoprotein Biosynthetic Process Centriole Replication Response To Thyroid Hormone Regulation Of Axon Extension Involved In Axon Guidance Venous Blood Vessel Development Glycosylceramide Metabolic Process Glycosphingolipid Biosynthetic Process Cellular Response To Stress Glycoprotein Metabolic Process Response To Stress Retina Vasculature Development In Camera-type Eye Lymph Vessel Development Negative Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of DNA Biosynthetic Process Synaptonemal Complex Assembly Cellular Metabolic Process Synaptonemal Complex Organization Oocyte Maturation Centriole Assembly Activin Receptor Signaling Pathway Male Meiosis I
Tagcloud ?		a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored	adrenaline approached ayurvedic clock digestive dilatation disturb external foods hemorrhoid hemorrhoidal hemorrhoids improper intero irregularity jimutaka kaphaja lepa lignocaine manual masses obliterating pile proctologists proctoscopic regularly sedentary sloughing visited
Tagcloud (Difference) ?		a375 abandoned aminoquinoline amodiaquine antimalarial antimalarials antimelanoma aq attracted autophagic cathepsins cdkn1a chemotherapeutic chloroquine crisis ctsb ctsd e2f1 lamp1 lc3 lysosomal oncological rb1 repurposing sqstm1 substantiated surpasses ultrastructural unexplored	adrenaline approached ayurvedic clock digestive dilatation disturb external foods hemorrhoid hemorrhoidal hemorrhoids improper intero irregularity jimutaka kaphaja lepa lignocaine manual masses obliterating pile proctologists proctoscopic regularly sedentary sloughing visited
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