CSN2 and NEK2

Number of citations of the paper that reports this interaction (PMID 15147269)
26

Data Source:
BioGRID (enzymatic study)

		CSN2	NEK2
Gene Name		casein beta	NIMA-related kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleolus Cytoplasm Centrosome Cytosol Microtubule Midbody Protein Complex Intercellular Bridge
	Molecular Function	Enzyme Inhibitor Activity Transporter Activity Calcium Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Metal Ion Binding
	Biological Process	Calcium Ion Transport Lactation Negative Regulation Of Catalytic Activity	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Organelle Organization Chromosome Segregation Mitotic Nuclear Division Regulation Of Mitotic Nuclear Division Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA Binding Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Negative Regulation Of Centriole-centriole Cohesion
Pathways		Nuclear signaling by ERBB4 Signaling by ERBB4	Organelle biogenesis and maintenance APC/C:Cdc20 mediated degradation of mitotic proteins Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: AURKA CDC42 CDK1 CELA1 CSN3 CSNK2A1 CSNK2B FHL2 GRB2 HTRA2 NEK1 NEK2 NEK8 NFYC PLK1 RAC1 TOLLIP	23 interactors: CCDC85A CEP250 CHGA CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PPP1CA PPP1CC PPP1R2 SPTBN4 TCF25 TPM3
Entrez ID		1447	4751
HPRD ID		00281	04953
Ensembl ID		ENSG00000135222	ENSG00000117650
Uniprot IDs		P05814	P51955
PDB IDs			2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development Mitotic Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Mitotic Nuclear Division Developmental Process Cell Projection Morphogenesis Cell Part Morphogenesis Mitotic Nuclear Division Regulation Of Organelle Organization Anatomical Structure Morphogenesis Neuron Development Neuron Projection Morphogenesis Regulation Of Cellular Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Axon Guidance Mitotic Cell Cycle Process Cell Morphogenesis Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Segregation Cell Division Neuron Differentiation Regulation Of Protein Metabolic Process Cell Projection Organization Centrosome Organization Regulation Of Cell Division Neuron Projection Development Regulation Of Binding Multicellular Organismal Development Microtubule Organizing Center Organization Positive Regulation Of Signal Transduction Wnt Signaling Pathway Cell Development Axonogenesis Protein Phosphorylation G2/M Transition Of Mitotic Cell Cycle Phosphorylation Cell Cycle Positive Regulation Of Protein Modification Process Cellular Protein Catabolic Process Regulation Of Cell Cycle Axon Development Regulation Of Metabolic Process Mitotic Nuclear Envelope Disassembly System Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Protein Stability Chemotaxis	Cell Cycle Regulation Of Centriole-centriole Cohesion Glycogen Metabolic Process Mitotic Cell Cycle Polysaccharide Metabolic Process Regulation Of Organelle Organization Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Movement Of Cell Or Subcellular Component Cell Cycle Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Energy Reserve Metabolic Process Mitotic Cell Cycle Process Microtubule-based Process Cell Division Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA-directed RNA Polymerase Activity Regulation Of Metaphase Plate Congression Regulation Of Cytoskeleton Organization Cellular Protein Localization Cellular Carbohydrate Metabolic Process Centrosome Cycle Cellular Response To Growth Factor Stimulus MAPK Import Into Nucleus Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Response To Growth Factor Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Chromosome Segregation Regulation Of Signal Transduction Cell Morphogenesis Circadian Regulation Of Gene Expression Energy Derivation By Oxidation Of Organic Compounds Response To Abiotic Stimulus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Oviduct Development Mitotic Nuclear Division Neuron Differentiation Establishment Of Organelle Localization
Tagcloud ?		0x 1x 25x 2x 4ebp1 4x 5x 8x arg arginine bovine casein conditionally csn1s csn1s1 csn1s2 csn3 devoid except excess experimental gland mammary mtor output resemble s6k stat5 true	called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 p45 proteasome proteolysis pull repeats seventh smc1 smc2 telophase
Tagcloud (Difference) ?		0x 1x 25x 2x 4ebp1 4x 5x 8x arg arginine bovine casein conditionally csn1s csn1s1 csn1s2 csn3 devoid except excess experimental gland mammary mtor output resemble s6k stat5 true	called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 p45 proteasome proteolysis pull repeats seventh smc1 smc2 telophase
Tagcloud (Intersection) ?