CSK and G3BP1

Number of citations of the paper that reports this interaction (PMID 15743820)
11

Data Source:
HPRD (in vivo)

		CSK	G3BP1
Gene Name		c-src tyrosine kinase	GTPase activating protein (SH3 domain) binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Stress Granule
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Protein C-terminus Binding Protein Phosphatase Binding Identical Protein Binding Proline-rich Region Binding	DNA Binding MRNA Binding ATP-dependent DNA Helicase Activity ATP-dependent RNA Helicase Activity Endonuclease Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Cytokine Production Morphogenesis Of An Epithelium Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Development Brain Development Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Low-density Lipoprotein Particle Clearance Cell Migration Cell Differentiation Platelet Activation T Cell Costimulation Negative Regulation Of Interleukin-6 Production Negative Regulation Of Kinase Activity Adherens Junction Organization Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Negative Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of MAP Kinase Activity Innate Immune Response Negative Regulation Of Bone Resorption Oligodendrocyte Differentiation Negative Regulation Of Phagocytosis T Cell Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Peptide Hormone Stimulus	Transport Ras Protein Signal Transduction Metabolic Process DNA Duplex Unwinding Negative Regulation Of Canonical Wnt Signaling Pathway Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Costimulation by the CD28 family GAB1 signalosome Integrin alphaIIb beta3 signaling Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Platelet Aggregation (Plug Formation) Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFR TCR signaling Signaling by EGFR in Cancer PD-1 signaling Platelet activation, signaling and aggregation Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs		Staurosporine
Diseases
GWAS		Blood pressure ( 21909110) Caffeine consumption ( 21490707) Diastolic blood pressure ( 19430479 19430483) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		46 interactors: ADRB2 ARRB1 CAV1 CD247 CD3E CD44 CDH5 CREBBP DAB2 DOK1 DOK3 FGR FHL2 FYN G3BP1 GJA1 GSN HCK HNRNPK ID3 IGF1R INSR KHDRBS1 LAIR1 LCK LYN MAPK15 PAG1 PECAM1 PLD2 PRKACA PTK2 PTPN12 PTPN18 PTPN22 PXN RASA1 RGS16 SDC3 SHC1 SIT1 SRC TGFB1I1 TLR3 ZAP70 ZNF212	11 interactors: APP CSK DTX1 EPHA8 FBXO25 HDAC6 IL7R LCK PIN1 RASA1 USP10
Entrez ID		1445	10146
HPRD ID		00496	06569
Ensembl ID		ENSG00000103653	ENSG00000145907
Uniprot IDs		A8K3B6 B2R6Q4 P41240	Q13283 Q5HYE9 Q5U0Q1 Q6ZP53
PDB IDs		1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ	3Q90 4FCJ 4FCM
Enriched GO Terms of Interacting Partners?		Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Communication Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Regulation Of Cell Adhesion Protein Autophosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Cellular Response To Peptide Hormone Stimulus Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Peptide Regulation Of Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Response To Peptide Hormone Immune System Process Regulation Of Intracellular Signal Transduction Response To Peptide Positive Regulation Of Protein Modification Process Positive Regulation Of Immune System Process Intracellular Signal Transduction Leukocyte Migration Positive Regulation Of Cellular Protein Metabolic Process Response To Hormone Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Response To Wounding Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Wound Healing Negative Regulation Of Signal Transduction Regulation Of T Cell Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Immune Response Innate Immune Response	Regulation Of Cell Adhesion Cellular Protein Modification Process Regulation Of Signal Transduction Cell Communication Regulation Of T Cell Activation Neuron Remodeling Cellular Protein Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Metabolic Process Regulation Of Lymphocyte Activation Regulation Of T Cell Differentiation Cellular Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Peptidyl-amino Acid Modification Regulation Of Lymphocyte Differentiation Regulation Of Cell Activation Signal Transduction Protein Metabolic Process Regulation Of Metabolic Process Signaling Platelet Activation Neuron Maturation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of T Cell Activation Protein Autophosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Locomotion Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell-cell Adhesion Immune Response Regulation Of Proteolysis Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stimulus Regulation Of Protein Metabolic Process Cell Activation Cell Differentiation Peptidyl-tyrosine Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Activation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Tagcloud ?		associate clone cloning cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shb shc spi2 stat5 superfamily transducers transfections	blockade bolster capsid counters cyclophilin cypa defences disassembles displacing eef2 gag groundwork imposed infectivity lay lifts loops overexposed preformed recruiting sg sgs sh3 silent stabilizes tiar translationally triage unsuspected
Tagcloud (Difference) ?		associate clone cloning cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shb shc spi2 stat5 superfamily transducers transfections	blockade bolster capsid counters cyclophilin cypa defences disassembles displacing eef2 gag groundwork imposed infectivity lay lifts loops overexposed preformed recruiting sg sgs sh3 silent stabilizes tiar translationally triage unsuspected
Tagcloud (Intersection) ?