FAM101A and FDFT1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		FAM101A	FDFT1
Gene Name		family with sequence similarity 101, member A	farnesyl-diphosphate farnesyltransferase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function		Farnesyl-diphosphate Farnesyltransferase Activity Oxidoreductase Activity Squalene Synthase Activity
	Biological Process		Steroid Biosynthetic Process Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Farnesyl Diphosphate Metabolic Process Oxidation-reduction Process
Pathways			Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Cholesterol biosynthesis Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005)
Protein-Protein Interactions		3 interactors: FBXW7 FDFT1 FLNA	6 interactors: ANXA5 ARL6IP1 FAM101A RUVBL2 SHPRH TMEM43
Entrez ID		144347	2222
HPRD ID		14066	01694
Ensembl ID		ENSG00000178882	ENSG00000079459
Uniprot IDs		Q6ZTI6	B4DT56 B4DWP0 B7Z1J3 P37268 Q6IAX1
PDB IDs			1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC
Enriched GO Terms of Interacting Partners?		Protein Stabilization Regulation Of Protein Stability Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Farnesyl Diphosphate Metabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of DNA Endoreduplication Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Catabolic Process Positive Regulation Of Oxidative Stress-induced Cell Death Posttranscriptional Regulation Of Gene Expression Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of DNA Endoreduplication Regulation Of Hepatocyte Proliferation MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity MRNA Transcription Regulation Of Triglyceride Biosynthetic Process Protein Localization To Cell Surface Mitotic Spindle Assembly Early Endosome To Late Endosome Transport Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Actin Crosslink Formation Positive Regulation Of ERBB Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasmic Sequestering Of Protein Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Regulation Of Epidermal Growth Factor-activated Receptor Activity Sister Chromatid Cohesion Negative Regulation Of Notch Signaling Pathway Cholesterol Biosynthetic Process Regulation Of Triglyceride Metabolic Process Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Isoprenoid Biosynthetic Process Platelet Aggregation Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Receptor Activity Sterol Biosynthetic Process Mitotic Spindle Organization Cell Cycle Process Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of DNA Replication Regulation Of Cellular Response To Oxidative Stress Receptor Clustering Epithelial To Mesenchymal Transition Regulation Of Lipid Storage	Negative Regulation Of Estrogen Receptor Binding Transcriptional Activation By Promoter-enhancer Looping Nuclear Membrane Organization Establishment Of Protein Localization To Chromatin DNA Conformation Change Negative Regulation Of Receptor Binding Protein Localization To Chromatin Histone H2A Acetylation
Tagcloud ?		adolescent ais built causing clustering clusters comp date differing drastic dysregulation elucidate grouped homeobox hoxa10 hoxa13 hoxb7 hoxb8 idiopathic integrity malfunctioning osteoblasts participate particular pathogenesis pitx1 scoliosis vertebrae zic2	abca1 biosynthesis brains cassette cholesterol debated extensively fdps genetically idi1 ldr lipids microarray mvd mvk notably nsdhl oligomeric oligomers plaques principal qpcr sc4mol steroid steroids toxic unexpected unresolved verified
Tagcloud (Difference) ?		adolescent ais built causing clustering clusters comp date differing drastic dysregulation elucidate grouped homeobox hoxa10 hoxa13 hoxb7 hoxb8 idiopathic integrity malfunctioning osteoblasts participate particular pathogenesis pitx1 scoliosis vertebrae zic2	abca1 biosynthesis brains cassette cholesterol debated extensively fdps genetically idi1 ldr lipids microarray mvd mvk notably nsdhl oligomeric oligomers plaques principal qpcr sc4mol steroid steroids toxic unexpected unresolved verified
Tagcloud (Intersection) ?