CS and MDH2

Number of citations of the paper that reports this interaction (PMID 7285903)
13

Data Source:
HPRD (in vitro)

		CS	MDH2
Gene Name		citrate synthase	malate dehydrogenase 2, NAD (mitochondrial)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Extracellular Vesicular Exosome	Nucleus Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Citrate (Si)-synthase Activity Poly(A) RNA Binding	L-malate Dehydrogenase Activity Protein Self-association Poly(A) RNA Binding Malate Dehydrogenase (NADP+) Activity
	Biological Process	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process Internal Protein Amino Acid Acetylation NADH Metabolic Process Pathogenesis Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process
Pathways		Mitochondrial protein import Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Metabolism of carbohydrates Citric acid cycle (TCA cycle)
Drugs			NADH Citric Acid
Diseases
GWAS		Height ( 23456168)
Protein-Protein Interactions		5 interactors: CRYAA CRYAB DYNLL1 HSPB1 MDH2	7 interactors: CRYAB CS FH GOT2 NDUFS1 PC WARS
Entrez ID		1431	4191
HPRD ID		00349	01099
Ensembl ID		ENSG00000062485	ENSG00000146701
Uniprot IDs		B4DJV2 O75390	B3KTM1 B4DE44 E9PDB2 G3XAL0 P40926
PDB IDs			2DFD
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Transport Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Intracellular Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Cellular Localization Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Protein Homooligomerization Tubulin Complex Assembly Positive Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Transport Negative Regulation Of Phosphorylation Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process NADH Metabolic Process Protein Oligomerization Oxaloacetate Metabolic Process Malate Metabolic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Intracellular Signal Transduction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Development Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Interleukin-1 Production Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Developmental Programmed Cell Death Microtubule Polymerization Or Depolymerization Substantia Nigra Development Platelet Aggregation Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Catalytic Activity Tricarboxylic Acid Cycle Cellular Response To Vascular Endothelial Growth Factor Stimulus	Fumarate Metabolic Process Dicarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Small Molecule Metabolic Process Oxaloacetate Metabolic Process Cellular Respiration Tricarboxylic Acid Cycle Energy Derivation By Oxidation Of Organic Compounds Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Gluconeogenesis Aerobic Respiration Hexose Biosynthetic Process Generation Of Precursor Metabolites And Energy Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Tryptophanyl-tRNA Aminoacylation Glucose Metabolic Process Carbohydrate Biosynthetic Process Aspartate Catabolic Process 4-hydroxyproline Catabolic Process L-kynurenine Metabolic Process Pathogenesis Hexose Metabolic Process Glutamate Catabolic Process Aspartate Metabolic Process Tubulin Complex Assembly Monosaccharide Metabolic Process Carbohydrate Metabolic Process Cellular Metabolic Process Biotin Metabolic Process Kynurenine Metabolic Process Dicarboxylic Acid Catabolic Process 2-oxoglutarate Metabolic Process Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation 4-hydroxyproline Metabolic Process Cellular Modified Amino Acid Catabolic Process Apoptotic Process Involved In Development Cellular Amino Acid Metabolic Process Glutamate Metabolic Process Oxidation-reduction Process Regulation Of Mitochondrial Membrane Potential Developmental Programmed Cell Death Microtubule Polymerization Or Depolymerization Monocarboxylic Acid Metabolic Process Homeostasis Of Number Of Cells Within A Tissue Negative Regulation Of Reactive Oxygen Species Metabolic Process
Tagcloud ?		ampar asparagine biionic ca2 channels equation exponent externally fluorometric flux glur glurs goldman hek hodgkin internally isoxazolepropionate katz nmdar overload pca pcs permeability permeable permeant q quantifying reflects transports	aggravating anxa1 banks bedside confidently cons fth1 ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Difference) ?		ampar asparagine biionic ca2 channels equation exponent externally fluorometric flux glur glurs goldman hek hodgkin internally isoxazolepropionate katz nmdar overload pca pcs permeability permeable permeant q quantifying reflects transports	aggravating anxa1 banks bedside confidently cons fth1 ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
Tagcloud (Intersection) ?