CRMP1 and EIF2S2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CRMP1	EIF2S2
Gene Name		collapsin response mediator protein 1	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Spindle Cytosol Dendrite Neuronal Cell Body	Cytosol Eukaryotic Translation Initiation Factor 2 Complex
	Molecular Function	Protein Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Axon Guidance	In Utero Embryonic Development Male Germ Cell Proliferation Translation Translational Initiation Male Gonad Development Gene Expression Cellular Protein Metabolic Process
Pathways		Axon guidance Semaphorin interactions CRMPs in Sema3A signaling	Ribosomal scanning and start codon recognition Recycling of eIF2:GDP Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494)	Breast cancer ( 22976474)
Protein-Protein Interactions		78 interactors: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DNAJB11 DPYSL2 DPYSL3 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LSM2 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1D1 ZAK ZNF24	22 interactors: APLP1 APP CCDC90B CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 HMGA1 KIAA1377 NCK1 PLEKHM1 PRKDC TLE1 TP53 UNC119 ZBTB16
Entrez ID		1400	8894
HPRD ID		03913	04882
Ensembl ID		ENSG00000072832	ENSG00000125977
Uniprot IDs		B3KT07 E9PD68 Q14194 Q96I11	P20042 Q6IBR8
PDB IDs		4B3Z
Enriched GO Terms of Interacting Partners?		Cell Death Death Developmental Process Apoptotic Process Programmed Cell Death Anatomical Structure Development Regulation Of Cellular Protein Metabolic Process Cell Differentiation Catabolic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Cellular Response To Stress Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Cysteine-type Endopeptidase Activity Response To Stimulus Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Organic Substance Protein Homooligomerization Response To Stress Protein Polyubiquitination Positive Regulation Of Protein Complex Assembly Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Nitrogen Compound Metabolic Process Cellular Response To Stimulus Multicellular Organismal Development Cytoskeleton Organization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Proteolysis Cellular Process Stress-activated MAPK Cascade Nervous System Development Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Cellular Component Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity System Development Positive Regulation Of Catalytic Activity Postreplication Repair Regulation Of Cellular Component Organization Protein Oligomerization Cellular Macromolecule Catabolic Process Positive Regulation Of Endopeptidase Activity Regulation Of Protein Complex Assembly Heterocycle Metabolic Process	Regulation Of Translation In Response To Stress Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Translational Initiation In Response To Stress Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Translational Initiation Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Nervous System Development Oligodendrocyte Development Central Nervous System Development Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Gene Expression Cell Development Negative Regulation Of Cellular Protein Metabolic Process Developmental Process Regulation Of Metabolic Process Neurogenesis Negative Regulation Of Protein Metabolic Process Cellular Response To Stimulus Oligodendrocyte Differentiation Anatomical Structure Development Negative Regulation Of Gene Expression System Development Negative Regulation Of Translation Translation Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Stimulus Glial Cell Development Response To Abiotic Stimulus Cellular Response To Stress Response To Heat Multicellular Organismal Development Response To Glucose Positive Regulation Of Protein Metabolic Process Cell Differentiation Rhythmic Process Positive Regulation Of Cell Aging Cellular Macromolecule Biosynthetic Process Cellular Protein Metabolic Process Response To Endoplasmic Reticulum Stress Macromolecule Biosynthetic Process B Cell Lineage Commitment
Tagcloud ?		aldh1a1 anxa1 bcar1 cldn1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	biosynthetic cd47 cycs dataset dj e2f6 encyclopedia extra fmr1 fxr2 gpr37 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34 unrecognized
Tagcloud (Difference) ?		aldh1a1 anxa1 bcar1 cldn1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	biosynthetic cd47 cycs dataset dj e2f6 encyclopedia extra fmr1 fxr2 gpr37 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34 unrecognized
Tagcloud (Intersection) ?