ADORA2B and ZNF267

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ADORA2B	ZNF267
Gene Name		adenosine A2b receptor	zinc finger protein 267
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Nucleus
	Molecular Function	G-protein Coupled Adenosine Receptor Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Adenosine Receptor Signaling Pathway Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Cellular Defense Response G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity JNK Cascade Excretion Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Guanylate Cyclase Activity Cellular Response To Extracellular Stimulus Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Mast Cell Degranulation Relaxation Of Vascular Smooth Muscle	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Nucleotide-like (purinergic) receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Adenosine P1 receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Generic Transcription Pathway
Drugs		Theophylline Adenosine Enprofylline Defibrotide
Diseases
GWAS		Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Protein-Protein Interactions		7 interactors: ADA DCC EZR NTN1 SLC9A3R2 TPD52L2 ZNF267	3 interactors: ADORA2B ATP6V0A1 EPHA7
Entrez ID		136	10308
HPRD ID		15971	06883
Ensembl ID		ENSG00000170425	ENSG00000185947
Uniprot IDs		P29275	Q14586
PDB IDs
Enriched GO Terms of Interacting Partners?		Anterior/posterior Axon Guidance Axon Guidance Negative Regulation Of Axonogenesis Regulation Of Cell Morphogenesis Negative Regulation Of Developmental Growth Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Deoxyadenosine Catabolic Process Xanthine Biosynthetic Process Single Organismal Cell-cell Adhesion Axonogenesis Negative Regulation Of Cell Morphogenesis Involved In Differentiation Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Neuron Projection Development Chemotaxis Negative Regulation Of Mucus Secretion Purine Deoxyribonucleoside Metabolic Process Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Neuron Projection Morphogenesis Regulation Of Cell Size Negative Regulation Of Cell Projection Organization Netrin-activated Signaling Pathway Spinal Cord Ventral Commissure Morphogenesis Germinal Center B Cell Differentiation Adenosine Catabolic Process DATP Catabolic Process Deoxyribonucleoside Catabolic Process Inosine Biosynthetic Process Hypoxanthine Salvage Negative Regulation Of Cell Growth Cell Morphogenesis Involved In Differentiation Regulation Of Axonogenesis Response To External Stimulus Neuron Migration Dorsal/ventral Axon Guidance Hypoxanthine Metabolic Process Hypoxanthine Biosynthetic Process Negative Regulation Of Mature B Cell Apoptotic Process Neuron Projection Development Negative Regulation Of Neuron Differentiation Membrane To Membrane Docking Cell Projection Morphogenesis Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Germinal Center Formation Positive Regulation Of Neuron Projection Development Negative Regulation Of Collateral Sprouting Neuron Development	Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Branching Morphogenesis Of A Nerve Vacuolar Proton-transporting V-type ATPase Complex Assembly Positive Regulation Of Chronic Inflammatory Response Relaxation Of Vascular Smooth Muscle Relaxation Of Smooth Muscle Positive Regulation Of Guanylate Cyclase Activity Vacuolar Acidification Positive Regulation Of Mast Cell Degranulation Regulation Of Chronic Inflammatory Response Adenosine Receptor Signaling Pathway Positive Regulation Of Mast Cell Activation Phosphate-containing Compound Metabolic Process Negative Regulation Of Smooth Muscle Contraction Regulation Of MAPK Cascade Positive Regulation Of CGMP Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Chemotaxis Positive Regulation Of CGMP Metabolic Process Positive Regulation Of Regulated Secretory Pathway Intracellular PH Reduction Negative Regulation Of Muscle Contraction Retinal Ganglion Cell Axon Guidance Relaxation Of Muscle PH Reduction Regulation Of CGMP Biosynthetic Process Regulation Of Mast Cell Degranulation Activation Of Adenylate Cyclase Activity Regulation Of Protein Autophosphorylation Regulation Of CGMP Metabolic Process Transferrin Transport ATP Synthesis Coupled Proton Transport Positive Regulation Vascular Endothelial Growth Factor Production Enzyme Linked Receptor Protein Signaling Pathway Vasodilation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Mast Cell Activation Regulation Of Regulated Secretory Pathway ATP Biosynthetic Process Positive Regulation Of Chemokine Production Phagosome Maturation Regulation Of Intracellular PH Excretion Regulation Of Protein Phosphorylation Regulation Of Cellular PH Positive Regulation Of Lyase Activity Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Smooth Muscle Contraction Cellular Defense Response
Tagcloud ?		acvrl1 agtrap angpt2 angptl4 apln cbf csrp2 ednra egfl7 ero1l flowmetry flt1 hi id1 immunolabeled iodoantipyrine kdr microvasculature mins nitroarginine normoxia nos3 nudt6 perimed pf5001 prrx1 serpine1 stereological
Tagcloud (Difference) ?		acvrl1 agtrap angpt2 angptl4 apln cbf csrp2 ednra egfl7 ero1l flowmetry flt1 hi id1 immunolabeled iodoantipyrine kdr microvasculature mins nitroarginine normoxia nos3 nudt6 perimed pf5001 prrx1 serpine1 stereological
Tagcloud (Intersection) ?