CP and GAST

Number of citations of the paper that reports this interaction (PMID 463490)
0

Data Source:
HPRD (in vitro)

		CP	GAST
Gene Name		ceruloplasmin (ferroxidase)	gastrin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosomal Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region
	Molecular Function	Ferroxidase Activity Copper Ion Binding Chaperone Binding	Hormone Activity Protein Binding
	Biological Process	Copper Ion Transport Cellular Iron Ion Homeostasis Transmembrane Transport Oxidation-reduction Process	Signal Transduction G-protein Coupled Receptor Signaling Pathway
Pathways		Metal ion SLC transporters Iron uptake and transport Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds SLC-mediated transmembrane transport	G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Drotrecogin alfa
Diseases
GWAS		Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		8 interactors: ATP7A BTRC GAST LTF MPO PLG PROC UBC	4 interactors: CP CPE MEP1B MME
Entrez ID		1356	2520
HPRD ID		00317	00671
Ensembl ID		ENSG00000047457	ENSG00000184502
Uniprot IDs		A5PL27 P00450	P01350
PDB IDs		1KCW 2J5W 4EJX 4ENZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Immune System Process Removal Of Superoxide Radicals Cellular Response To Superoxide Response To Superoxide Defense Response To Fungus Response To Oxygen Radical Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteolysis Regulation Of Cell Death Response To Fungus Superoxide Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Response To Stress Negative Regulation Of Wound Healing Response To Stimulus Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Iron Assimilation By Chelation And Transport Hypochlorous Acid Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Elastin Biosynthetic Process Plasma Membrane Copper Ion Transport Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Blood Coagulation Cellular Response To Reactive Oxygen Species Reactive Oxygen Species Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Tissue Remodeling Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Antifungal Humoral Response Positive Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of Chondrocyte Proliferation Copper Ion Export Negative Regulation Of Osteoclast Development Response To Gold Nanoparticle Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Body Fluid Levels	Peptide Hormone Processing Peptide Metabolic Process Hormone Metabolic Process Cellular Response To UV-A Protein Processing Cellular Amide Metabolic Process Regulation Of Hormone Levels Creatinine Metabolic Process Insulin Processing Response To UV-A Proteolysis Cellular Response To UV-B Insulin Metabolic Process Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Cardiac Left Ventricle Morphogenesis Response To UV-B Replicative Senescence Beta-amyloid Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Copper Ion Transport Toxin Transport Cellular Response To UV Cardiac Ventricle Morphogenesis Cell Aging Cellular Iron Ion Homeostasis
Tagcloud ?		airways anesthetized artificially attacks breaths bronchoconstriction citric clarified counteracts endogenously gastroesophageal guinea halved hoe implication inhalation inhaled micromol nerves nk1 nk2 nmma reflux rl sr submaximum tachykinin tachykinins ventilated	17q 17q12 amplicon amplification amplifications amplified anthracycline besides ccr7 concerning grb7 heterogeneity heterogeneous igfpb4 iia implications krt19 krt20 locus med1 pitfalls presents rara stard3 subgroup thra top2a topoisomerase variations
Tagcloud (Difference) ?		airways anesthetized artificially attacks breaths bronchoconstriction citric clarified counteracts endogenously gastroesophageal guinea halved hoe implication inhalation inhaled micromol nerves nk1 nk2 nmma reflux rl sr submaximum tachykinin tachykinins ventilated	17q 17q12 amplicon amplification amplifications amplified anthracycline besides ccr7 concerning grb7 heterogeneity heterogeneous igfpb4 iia implications krt19 krt20 locus med1 pitfalls presents rara stard3 subgroup thra top2a topoisomerase variations
Tagcloud (Intersection) ?