COL17A1 and ITGA6

Number of citations of the paper that reports this interaction (PMID 11739652)
9

Data Source:
HPRD (in vivo, two hybrid)

		COL17A1	ITGA6
Gene Name		collagen, type XVII, alpha 1	integrin, alpha 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Hemidesmosome	Basement Membrane Plasma Membrane Cell-cell Adherens Junction Focal Adhesion External Side Of Plasma Membrane Basal Plasma Membrane Cell Surface Hemidesmosome Filopodium Integrin Alpha6-beta4 Complex
	Molecular Function	Protein Binding	Integrin Binding Protein Binding Laminin Binding Metal Ion Binding
	Biological Process	Cell-matrix Adhesion Epidermis Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Hemidesmosome Assembly Cell Junction Assembly	Cell-substrate Junction Assembly Cell-matrix Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Ectodermal Cell Differentiation Positive Regulation Of Cell-substrate Adhesion Single Organismal Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Hemidesmosome Assembly Cell-substrate Adhesion Cellular Response To Extracellular Stimulus Cell Adhesion Mediated By Integrin Cell Junction Assembly Nail Development Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Skin Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Filopodium Assembly Digestive Tract Development Brown Fat Cell Differentiation Leukocyte Migration Cellular Response To Organic Cyclic Compound Renal System Development Amelogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Cell junction organization Type I hemidesmosome assembly Collagen formation Collagen degradation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Cell junction organization Syndecan interactions Type I hemidesmosome assembly Collagen formation Laminin interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions Assembly of collagen fibrils and other multimeric structures Basigin interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Cardiac hypertrophy ( 21348951)	Alzheimer's disease biomarkers ( 23419831) Prostate cancer ( 19767753)
Protein-Protein Interactions		12 interactors: ACTN1 ACTN4 CLSTN1 CTNND1 DSP DST ITGA6 ITGB4 KRT18 LAD1 PLEC PPL	21 interactors: ADAM9 APP BIN1 CALM1 CANX CD151 CD36 CD63 CD82 COL17A1 GIPC1 GRB2 ITGB1 ITGB4 PCSK5 PLEC PRKCD PXN RABIF RPSA TSPAN4
Entrez ID		1308	3655
HPRD ID		00223	00945
Ensembl ID		ENSG00000065618	ENSG00000091409
Uniprot IDs		Q9UMD9	P23229
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Junction Assembly Hemidesmosome Assembly Cell-substrate Junction Assembly Protein Localization To Cell Junction Protein Localization To Tight Junction Cell Adhesion Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cell-cell Junction Organization Skin Development Cellular Component Assembly Nail Development Adherens Junction Organization Integrin-mediated Signaling Pathway Amelogenesis Actin Crosslink Formation Filopodium Assembly Cell-matrix Adhesion Cytoskeleton Organization Cell-substrate Adhesion Wound Healing Tight Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Actin Filament Bundle Assembly Platelet Degranulation Golgi To Plasma Membrane CFTR Protein Transport Apical Junction Assembly Execution Phase Of Apoptosis Keratinocyte Differentiation Blood Coagulation Hemostasis Ventricular Compact Myocardium Morphogenesis Odontogenesis Of Dentin-containing Tooth Cell-cell Junction Assembly Positive Regulation Of Pinocytosis Single Organismal Cell-cell Adhesion Odontogenesis Positive Regulation Of Sodium:proton Antiporter Activity Protein Localization To Adherens Junction Epidermal Cell Differentiation Digestive Tract Development Regulation Of Body Fluid Levels Digestive System Development Response To Stress Regulation Of Sodium:proton Antiporter Activity Ectodermal Cell Differentiation Peroxisome Proliferator Activated Receptor Signaling Pathway	Hemidesmosome Assembly Cell-substrate Junction Assembly Cell Activation Cell-matrix Adhesion Cell Junction Assembly Cell Adhesion Platelet Activation Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Blood Coagulation Hemostasis Response To Wounding Cellular Component Assembly Secretion By Cell Regulation Of Body Fluid Levels Platelet Degranulation Response To Growth Factor Wound Healing Secretion Positive Regulation Of Endocytosis Positive Regulation Of Transport Integrin-mediated Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Regulation Of MAPK Cascade Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Endocytosis Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Endocytosis Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Movement Of Cell Or Subcellular Component Establishment Of Localization In Cell Regulation Of Protein Phosphorylation Cell-cell Adhesion Mediated By Integrin Response To Oxidative Stress Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Transport Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Immune System Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway
Tagcloud ?		aligning alopecia atrophic blistering bullosa codons corrective correlating dystrophy enamel epidermolysis exons faulty harbouring herlitz hypoplasia introns jeb junctional milder mucous nail nh nonsense pitting premtrna repaired vicinity xvii
Tagcloud (Difference) ?		aligning alopecia atrophic blistering bullosa codons corrective correlating dystrophy enamel epidermolysis exons faulty harbouring herlitz hypoplasia introns jeb junctional milder mucous nail nh nonsense pitting premtrna repaired vicinity xvii
Tagcloud (Intersection) ?