ADH4 and RPL35

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ADH4	RPL35
Gene Name		alcohol dehydrogenase 4 (class II), pi polypeptide	ribosomal protein L35
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleolus Cytoplasm Cytosol Membrane Cytosolic Large Ribosomal Subunit
	Molecular Function	NADPH:quinone Reductase Activity Alcohol Dehydrogenase (NAD) Activity Alcohol Dehydrogenase Activity, Zinc-dependent Alditol:NADP+ 1-oxidoreductase Activity Retinol Dehydrogenase Activity All-trans Retinal Binding Zinc Ion Binding Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Benzaldehyde Dehydrogenase Activity Retinol Binding Ethanol Binding NAD Binding	MRNA Binding Structural Constituent Of Ribosome Poly(A) RNA Binding
	Biological Process	Retinoid Metabolic Process Alcohol Metabolic Process Ethanol Oxidation Cellular Aldehyde Metabolic Process Xenobiotic Metabolic Process Retinol Metabolic Process Small Molecule Metabolic Process Alcohol Catabolic Process Quinone Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Ethanol oxidation Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Biological oxidations RA biosynthesis pathway Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Signaling by Retinoic Acid Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs		NADH Nicotinamide-Adenine-Dinucleotide Cyclohexylformamide
Diseases
GWAS		Alcohol dependence ( 23456092) Esophageal cancer (alcohol interaction) ( 22960999)
Protein-Protein Interactions		2 interactors: APP RPL35	7 interactors: ACTN2 ADH4 CDKN1A LAMC3 MAX SGSM3 TUBB2B
Entrez ID		127	11224
HPRD ID		00068	10200
Ensembl ID		ENSG00000198099	ENSG00000136942
Uniprot IDs		P08319	P42766
PDB IDs		3COS	3J3B
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition MRNA Metabolic Process Neuron Remodeling Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Intracellular Transport Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Associative Learning Developmental Cell Growth Establishment Of Localization In Cell Viral Transcription Regulation Of Synapse Structure Or Activity Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Feeding Behavior Cotranslational Protein Targeting To Membrane
Tagcloud ?		actors adh3 adhs conjunctiva conjunctival cornea corneal crabp1 crabp2 crabps crbp crbp1 crbps cyp26 dehydrogenases dependant dhrs4 dhrs9 exhaustive histochemistry keratocytes ocular raldh1 raldh3 raldhs retinol rodh4 rxrs sdr
Tagcloud (Difference) ?		actors adh3 adhs conjunctiva conjunctival cornea corneal crabp1 crabp2 crabps crbp crbp1 crbps cyp26 dehydrogenases dependant dhrs4 dhrs9 exhaustive histochemistry keratocytes ocular raldh1 raldh3 raldhs retinol rodh4 rxrs sdr
Tagcloud (Intersection) ?