CLK1 and PDE9A

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CLK1	PDE9A
Gene Name		CDC-like kinase 1	phosphodiesterase 9A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Endoplasmic Reticulum Golgi Apparatus Cytosol Ruffle Membrane Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity ATP Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity Protein Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Cell Proliferation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation	Signal Transduction Blood Coagulation Metabolic Process CGMP-mediated Signaling
Pathways			Platelet homeostasis Nitric oxide stimulates guanylate cyclase cGMP effects
Drugs		Debromohymenialdisine ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
Diseases
GWAS
Protein-Protein Interactions		20 interactors: BCLAF1 GOLM1 KRTAP10-7 LUC7L3 MBP NCOR1 PDE9A PIAS4 PPIG PRMT5 PRPF4 PTPN1 SAFB SRPK1 SRPK2 SRSF1 SRSF3 SRSF6 UBL5 YWHAG	18 interactors: BAG3 C9orf106 CLK1 CRY2 GORASP2 KRTAP10-3 KRTAP10-8 KRTAP4-2 KRTAP9-2 LAGE3 LMO2 NAA38 NOTCH2NL PHYHIPL SULT1E1 TRIM32 TRPV6 UTP23
Entrez ID		1195	5152
HPRD ID		09058	09115
Ensembl ID		ENSG00000013441	ENSG00000160191
Uniprot IDs		P49759	O76083
PDB IDs		1Z57 2VAG	2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing, Via Transesterification Reactions MRNA Processing MRNA Metabolic Process RNA Metabolic Process Gene Expression Spliceosomal Complex Assembly Ribonucleoprotein Complex Assembly Regulation Of MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process MRNA Splice Site Selection Ribonucleoprotein Complex Biogenesis Termination Of RNA Polymerase II Transcription Nitrogen Compound Metabolic Process MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing RNA 3'-end Processing Cellular Macromolecular Complex Assembly Nuclear Export MRNA Transport Nucleus Organization Positive Regulation Of Viral Genome Replication RNA Transport Transcription, DNA-templated RNA Localization RNA Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Viral Genome Replication Negative Regulation Of Cellular Metabolic Process Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear Speck Organization Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Response To DNA Damage Stimulus Nucleocytoplasmic Transport Nuclear Transport Positive Regulation Of Cell Death Cellular Metabolic Process Regulation Of Viral Genome Replication
Tagcloud ?		10q 11q 13q 14q 15q 1q 21q 2q 3p 3q 4q 6q 8q 9q aberration acsl1 ethnicities gains governing incurable karyotypes lyst malaysia malaysian myeloma nfkbia penetrance predispositions xq	acetylcholinesterase adas aes cgi cgmp cog cognition diarrhea discontinuation elevates guanoscine impression memantine mini mmse monophosphate nausea neuropsychiatric npi overexpress pf pharmacokinetics phosphodiesterase placebo probable q12h subscale tg2576
Tagcloud (Difference) ?		10q 11q 13q 14q 15q 1q 21q 2q 3p 3q 4q 6q 8q 9q aberration acsl1 ethnicities gains governing incurable karyotypes lyst malaysia malaysian myeloma nfkbia penetrance predispositions xq	acetylcholinesterase adas aes cgi cgmp cog cognition diarrhea discontinuation elevates guanoscine impression memantine mini mmse monophosphate nausea neuropsychiatric npi overexpress pf pharmacokinetics phosphodiesterase placebo probable q12h subscale tg2576
Tagcloud (Intersection) ?