CLIC1 and ALOX5AP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CLIC1	ALOX5AP
Gene Name		chloride intracellular channel 1	arachidonate 5-lipoxygenase-activating protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nuclear Envelope Cytoplasm Mitochondrion Plasma Membrane Brush Border Membrane Nuclear Membrane Vesicle Chloride Channel Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein Binding	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Protein N-terminus Binding Arachidonic Acid Binding
	Biological Process	Chloride Transport Signal Transduction Regulation Of Ion Transmembrane Transport Positive Regulation Of Osteoblast Differentiation Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Platelet Aggregation Chloride Transmembrane Transport	Leukotriene Metabolic Process Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Catalytic Activity Small Molecule Metabolic Process Protein Homotrimerization Cellular Response To Calcium Ion Lipoxin Metabolic Process
Pathways			Arachidonic acid metabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Synthesis of Lipoxins (LX) Synthesis of Leukotrienes (LT) and Eoxins (EX)
Drugs
Diseases
GWAS			Non-word repetition ( 23738518)
Protein-Protein Interactions		19 interactors: AKAP9 ALOX5AP ATP5F1 ATP6V0A1 ATP6V0C CPT1A IKBKG LSM1 MYOC NTF4 NUP62 PRDX4 PSMD10 RPLP1 SUMO4 THRA TRAPPC2 ZNF184 ZNF302	3 interactors: ALOX5 CLIC1 LTC4S
Entrez ID		1192	241
HPRD ID		04188	04742
Ensembl ID		ENSG00000213719	ENSG00000132965
Uniprot IDs		O00299 Q5SRT3	P20292
PDB IDs		1K0M 1K0N 1K0O 1RK4 3O3T 3P8W 3P90 3QR6 3SWL 3TGZ 3UVH 4IQA	2Q7M 2Q7R
Enriched GO Terms of Interacting Partners?		Nitrogen Compound Metabolic Process Viral Process Cellular Nitrogen Compound Metabolic Process Cytoplasmic Sequestering Of Transcription Factor Gene Expression Cytoplasmic Sequestering Of Protein Cellular Metabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Localization Heterocycle Metabolic Process Transferrin Transport ATP Synthesis Coupled Proton Transport Hydrogen Ion Transmembrane Transport ATP Biosynthetic Process Phagosome Maturation Proton Transport Negative Regulation Of Transcription Factor Import Into Nucleus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Lipid Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Male Germ Cell Proliferation Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Sensory Organ Boundary Specification Negative Regulation Of Small GTPase Mediated Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Hormone Stimulus Nucleobase-containing Compound Metabolic Process ATP Hydrolysis Coupled Proton Transport Regulation Of MAPK Cascade Cellular Response To Stimulus Negative Regulation Of Protein Import Into Nucleus Small Molecule Metabolic Process Cellular Aromatic Compound Metabolic Process Monovalent Inorganic Cation Transport Purine Ribonucleoside Monophosphate Biosynthetic Process Biosynthetic Process RNA Biosynthetic Process Taste Bud Development ERBB2 Signaling Pathway Ganglion Mother Cell Fate Determination Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Protein Localization To Nucleus RNA Metabolic Process Iron Ion Transport Cellular Iron Ion Homeostasis Nucleoside Triphosphate Biosynthetic Process Negative Regulation Of Intracellular Protein Transport Regulation Of Transcription Factor Import Into Nucleus	Lipoxin Metabolic Process Lipoxygenase Pathway Leukotriene Biosynthetic Process Leukotriene Metabolic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Arachidonic Acid Metabolic Process Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Leukotriene Production Involved In Inflammatory Response Fatty Acid Metabolic Process Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Production Of Molecular Mediator Involved In Inflammatory Response Regulation Of Mitochondrial Membrane Potential Cellular Lipid Metabolic Process Platelet Aggregation Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Lipid Metabolic Process Positive Regulation Of Osteoblast Differentiation Oxidation-reduction Process Positive Regulation Of Ossification Chloride Transmembrane Transport Regulation Of Osteoblast Differentiation Chloride Transport
Tagcloud ?		aava accelerates atpase consolidating deregulated eevd endogenously enough gankyrin hek hot hub integrating interfaces mb mda migratory mutagenesis networks oncogenic oncoprotein pdb polypharmacological proteasome reflecting rescue searching silenced spot	acat acyltransferase arachidonate ath atherosclerotic cbs cysthathionenine deceased gathered genomelab gexp hcats irs1 lcat ldlr lecithin lipoxygenase lpl malaysian metallopeptidase methylenetetrahydrofolate mmp9 mortem mthfr ncat predetermined tgfbr2 thbd thrombomodulin
Tagcloud (Difference) ?		aava accelerates atpase consolidating deregulated eevd endogenously enough gankyrin hek hot hub integrating interfaces mb mda migratory mutagenesis networks oncogenic oncoprotein pdb polypharmacological proteasome reflecting rescue searching silenced spot	acat acyltransferase arachidonate ath atherosclerotic cbs cysthathionenine deceased gathered genomelab gexp hcats irs1 lcat ldlr lecithin lipoxygenase lpl malaysian metallopeptidase methylenetetrahydrofolate mmp9 mortem mthfr ncat predetermined tgfbr2 thbd thrombomodulin
Tagcloud (Intersection) ?