ADD2 and ADD1

Number of citations of the paper that reports this interaction (PMID 7490111)
0

Data Source:
HPRD (in vivo)

		ADD2	ADD1
Gene Name		adducin 2 (beta)	adducin 1 (alpha)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane F-actin Capping Protein Complex Cytoplasmic Membrane-bounded Vesicle	Nucleus Nucleoplasm Cytosol Plasma Membrane Focal Adhesion F-actin Capping Protein Complex Postsynaptic Density Dendritic Spine Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Structural Molecule Activity Calmodulin Binding Spectrin Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	Actin Binding Structural Molecule Activity Calmodulin Binding Transcription Factor Binding Spectrin Binding T Cell Receptor Binding Protein Homodimerization Activity Poly(A) RNA Binding Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Protein Complex Assembly Actin Cytoskeleton Organization Hemopoiesis Positive Regulation Of Protein Binding Barbed-end Actin Filament Capping Actin Filament Bundle Assembly	Cell Morphogenesis In Utero Embryonic Development Cell Volume Homeostasis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Hemoglobin Metabolic Process Actin Cytoskeleton Organization Erythrocyte Differentiation Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Binding Multicellular Organism Growth Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Endocytosis Homeostasis Of Number Of Cells Within A Tissue Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Cellular Response To Retinoic Acid
Pathways			Apoptotic cleavage of cellular proteins IRE1alpha activates chaperones Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ADD1 APP CALM1 FYN PRKACA PRKCD PTPRZ1 RPH3A	21 interactors: ADD2 ATP1A1 CALM1 CASP3 CSNK2B GEMIN7 HMG20A HSPH1 ID2 ID3 MAP1LC3B PRKACA PRKCD RFX1 ROCK1 SMARCC1 SPTA1 SPTAN1 SPTB TK1 ZDHHC17
Entrez ID		119	118
HPRD ID		00037	00036
Ensembl ID		ENSG00000075340	ENSG00000087274
Uniprot IDs		P35612 Q05DK5	A2A3N8 P35611 Q86XM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Coagulation Regulation Of Protein Binding Hemostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune System Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Body Fluid Levels Activation Of Phospholipase C Activity Neurotrophin Signaling Pathway Wound Healing Positive Regulation Of Phospholipase C Activity Regulation Of Binding Cell Activation Response To Wounding Regulation Of Protein Kinase Activity Positive Regulation Of Phospholipase Activity Regulation Of Kinase Activity Innate Immune Response Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Hydrolase Activity Regulation Of Protein Phosphorylation Regulation Of Platelet Aggregation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Protein Metabolic Process Detection Of Abiotic Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Dephosphorylation Cellular Response To Growth Factor Stimulus Immune Response Regulation Of Phosphorylation Response To Growth Factor Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Defense Response Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Regulation Of Peptidyl-tyrosine Phosphorylation	Negative Regulation Of Actin Filament Polymerization Response To External Stimulus Negative Regulation Of Protein Polymerization Regulation Of Actin Filament-based Process Regulation Of Binding Nervous System Development Negative Regulation Of Protein Complex Assembly Actin Filament Capping Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Actin Filament Depolymerization Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Execution Phase Of Apoptosis Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length System Development Negative Regulation Of Protein Complex Disassembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Stimulus Regulation Of Cell Activation Regulation Of Protein Depolymerization Neuron Differentiation Generation Of Neurons Developmental Process Regulation Of Cytoskeleton Organization Regulation Of Protein Complex Disassembly Multicellular Organismal Development Immune System Process Neurogenesis Anatomical Structure Development Cellular Metabolic Process Regulation Of Protein Binding Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Chemotaxis Regulation Of Cell Adhesion Activation Of Phospholipase C Activity Anatomical Structure Morphogenesis Regulation Of Cell-cell Adhesion Positive Regulation Of Phospholipase C Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Cell Morphogenesis Involved In Differentiation Negative Regulation Of Glial Cell Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cardiac Muscle Contraction Neurotrophin Signaling Pathway Positive Regulation Of Phospholipase Activity
Tagcloud ?		2p13 4p16 acceptor adducin alternative alternatively codons comprises conform consensus duplication ets exon exons frame gata intron isoform mapping mzf1 overlapping smallest sp1 spans splice spliced stop termination utr	arnt2 asked camk2g cstb ctgf downregulated dr1 epas1 globin gna11 hif1a hypoxic il6st khsrp mars multitude neuroglobin neuroprotection ngb o4 ogd pea15 r4 reoxygenation rest spatially temporally tg wt
Tagcloud (Difference) ?		2p13 4p16 acceptor adducin alternative alternatively codons comprises conform consensus duplication ets exon exons frame gata intron isoform mapping mzf1 overlapping smallest sp1 spans splice spliced stop termination utr	arnt2 asked camk2g cstb ctgf downregulated dr1 epas1 globin gna11 hif1a hypoxic il6st khsrp mars multitude neuroglobin neuroprotection ngb o4 ogd pea15 r4 reoxygenation rest spatially temporally tg wt
Tagcloud (Intersection) ?