TOE1 and WDR83

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		TOE1	WDR83
Gene Name		target of EGR1, member 1 (nuclear)	WD repeat domain 83
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Speck	Spliceosomal Complex Cytoplasm Catalytic Step 2 Spliceosome
	Molecular Function	Nucleic Acid Binding Protein Binding Metal Ion Binding	Protein Binding
	Biological Process		RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: ABCF3 AGGF1 AP2A1 APLP1 CA12 HNRNPF IK IL7R LSM4 PPP1CA PRCC RAB40C RBM39 RBM8A RPS3A SF3B2 SF3B3 SH3GL3 SQSTM1 SRSF6 SUMO1 U2AF1 UNC13B WDR77 WDR83	17 interactors: AQR BAG2 CRB3 EGLN3 GNB2L1 GPKOW HNRNPH2 HSPB1 KDM1A KEAP1 LSM3 PARD6A PARD6B PCBP2 SAP30BP SF1 TOE1
Entrez ID		114034	84292
HPRD ID		18212	14730
Ensembl ID		ENSG00000132773	ENSG00000123154
Uniprot IDs		B4DEM6 Q96GM8	Q9BRX9
PDB IDs		2FC6
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process RNA Processing MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA 3'-end Processing RNA 3'-end Processing RNA Metabolic Process Termination Of RNA Polymerase II Transcription Gene Expression Nucleobase-containing Compound Metabolic Process MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Nuclear Export MRNA Transport Nitrogen Compound Metabolic Process RNA Transport Regulation Of Alternative MRNA Splicing, Via Spliceosome Cellular Localization Nuclear-transcribed MRNA Catabolic Process RNA Localization MRNA Catabolic Process Cytoplasmic Transport Establishment Of Localization In Cell Intracellular Transport RNA Catabolic Process Positive Regulation Of Synaptic Vesicle Priming Positive Regulation Of Synaptic Vesicle Exocytosis Interleukin-7-mediated Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome Nucleocytoplasmic Transport Cellular Metabolic Process Nuclear Transport Negative Regulation Of Hyaluronan Biosynthetic Process Cellular Response To Norepinephrine Stimulus Regulation Of Epithelial Cell Proliferation Regulation Of MRNA Processing PML Body Organization Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Negative Regulation Of T Cell Mediated Cytotoxicity Cellular Process	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Tight Junction Assembly MRNA Processing Apical Junction Assembly MRNA Metabolic Process RNA Processing Cell-cell Junction Assembly Gene Expression Negative Regulation Of Oxidative Stress-induced Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Cell Junction Assembly Cell-cell Junction Organization Regulation Of Cellular Response To Oxidative Stress RNA Metabolic Process Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of CAMP Catabolic Process Heterocycle Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Zymogen Activation Negative Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Primary Sex Determination Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Proteasomal Ubiquitin-independent Protein Catabolic Process Regulation Of Embryonic Development Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway MRNA 3'-splice Site Recognition Positive Regulation Of Endopeptidase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Female Gonad Development Nitrogen Compound Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Peptidase Activity Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Histone H3-K4 Methylation
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