CHRNA7 and ADCY6

Number of citations of the paper that reports this interaction (PMID 12748066)
11

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CHRNA7	ADCY6
Gene Name		cholinergic receptor, nicotinic, alpha 7 (neuronal)	adenylate cyclase 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Cell Junction Postsynaptic Membrane	Plasma Membrane Cilium Membrane Integral Component Of Membrane
	Molecular Function	Beta-amyloid Binding Acetylcholine-activated Cation-selective Channel Activity Acetylcholine Receptor Activity Toxic Substance Binding Chloride Channel Regulator Activity Acetylcholine-gated Cation Channel Activity Acetylcholine Binding Protein Homodimerization Activity	Adenylate Cyclase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Response To Hypoxia Ion Transport Calcium Ion Transport Cellular Calcium Ion Homeostasis Signal Transduction Synaptic Transmission Memory Positive Regulation Of Cell Proliferation Negative Regulation Of Tumor Necrosis Factor Production Ion Transmembrane Transport Response To Nicotine Positive Regulation Of Angiogenesis Cognition Cation Transmembrane Transport	Renal Water Homeostasis Energy Reserve Metabolic Process CAMP Biosynthetic Process Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Dopamine Receptor Signaling Pathway Synaptic Transmission Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Neuron Projection Development Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Transmembrane Transport Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Acetylcholine Binding And Downstream Events Activation of Nicotinic Acetylcholine Receptors Postsynaptic nicotinic acetylcholine receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses	Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Phospholipase C-mediated cascade Integration of energy metabolism Signaling by FGFR in disease Activation of GABAB receptors G alpha (s) signalling events Signaling by EGFRvIII in Cancer Adenylate cyclase activating pathway PLCG1 events in ERBB2 signaling DAP12 signaling G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Aquaporin-mediated transport EGFR interacts with phospholipase C-gamma Adrenaline,noradrenaline inhibits insulin secretion Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB GPCR downstream signaling Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer PKA activation Transmission across Chemical Synapses DAG and IP3 signaling CaM pathway Downstream signaling of activated FGFR Innate Immune System GABA B receptor activation GABA receptor activation Adenylate cyclase inhibitory pathway PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway Signaling by Hedgehog PLC-gamma1 signalling
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: ADCY6 APP ATXN1 PIK3R1	4 interactors: ATXN1 CHRNA7 GNAS RAF1
Entrez ID		1139	112
HPRD ID		00339	02621
Ensembl ID			ENSG00000174233
Uniprot IDs		P36544	O43306
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Phosphorylation Response To Light Stimulus Regulation Of Phosphorus Metabolic Process Response To Radiation Visual Learning Visual Behavior Regulation Of Body Fluid Levels Associative Learning Negative Regulation Of Cell Differentiation Adult Locomotory Behavior Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Innate Immune Response NFAT Protein Import Into Nucleus Chemical Homeostasis Learning Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Adult Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Factor Import Into Nucleus Synaptic Growth At Neuromuscular Junction Cellular Response To Fibroblast Growth Factor Stimulus Response To Abiotic Stimulus Negative Regulation Of Neuron Differentiation Platelet Activation Response To Fibroblast Growth Factor Positive Regulation Of Metabolic Process Collateral Sprouting In Absence Of Injury Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Locomotory Behavior Immune Response Positive Regulation Of Transcription, DNA-templated Defense Response Nucleocytoplasmic Transport Learning Or Memory Nuclear Transport Homeostatic Process Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Neurogenesis Cognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Macromolecule Biosynthetic Process System Development Cellular Response To Peptide Hormone Stimulus Intracellular Transport	Cognition Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Lyase Activity Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Synaptic Transmission Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Death-inducing Signaling Complex Assembly Post-embryonic Body Morphogenesis Response To Organonitrogen Compound Regulation Of Signal Transduction Cell-cell Signaling Regulation Of Signaling Response To Abiotic Stimulus Platelet Activation Positive Regulation Of Metabolic Process Neurological System Process Positive Regulation Of Signal Transduction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Phosphorylation Learning Or Memory Activation Of Protein Kinase Activity Response To Hypoxia Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Catalytic Activity Cellular Response To Peptide Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Transmembrane Transport Blood Coagulation Hemostasis Transport Positive Regulation Of MAPK Cascade Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Single-organism Behavior Response To Peptide Hormone Cellular Response To Prostaglandin E Stimulus Response To Parathyroid Hormone Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Positive Regulation Of CAMP-mediated Signaling
Tagcloud ?		akr1c4 anomalies apparently array balanced bases cdon cgh confirming dd diagnoses dock8 gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63
Tagcloud (Difference) ?		akr1c4 anomalies apparently array balanced bases cdon cgh confirming dd diagnoses dock8 gata3 id indistinguishable inherited intellectual karyotype karyotyping mb mca nr2f2 overlooked prenatal pws rearrangements spanning tier tp63
Tagcloud (Intersection) ?