LYST and DGCR14

Number of citations of the paper that reports this interaction (PMID 11984006)
18

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, two hybrid)

		LYST	DGCR14
Gene Name		lysosomal trafficking regulator	DiGeorge syndrome critical region gene 14
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Endomembrane System Microtubule Cytoskeleton Extrinsic Component Of Membrane	Nucleus Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Phospholipid Binding	Molecular_function Protein Binding
	Biological Process	Neutrophil Mediated Immunity T Cell Mediated Immunity Phospholipid Metabolic Process Microtubule-based Process Lysosome Organization Blood Coagulation Leukocyte Chemotaxis Melanosome Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of Natural Killer Cell Activation Secretion Of Lysosomal Enzymes Mast Cell Secretory Granule Organization Natural Killer Cell Mediated Cytotoxicity Response To Drug Defense Response To Bacterium Defense Response To Protozoan Pigmentation Defense Response To Virus Phospholipid Homeostasis	MRNA Splicing, Via Spliceosome Nervous System Development
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ATN1 CALM1 CELF4 CENPJ CNTROB CSNK2B DGCR14 DNAJC14 EFS ESRRA HGS HNRNPM KPNB1 MED12 MRPL17 MRPS31 NCDN PCBP4 TNNI3 VTA1 YWHAB YWHAQ YWHAZ ZNF521	11 interactors: CDK5RAP3 CRP DHX16 FRA10AC1 GNB2L1 LYST PFDN1 RBM4 TTC14 VIM WNK2
Entrez ID		1130	8220
HPRD ID		06060	03452
Ensembl ID		ENSG00000143669	ENSG00000100056
Uniprot IDs		Q99698	Q96DF8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Mitochondrion Organization Protein Targeting Alternative MRNA Splicing, Via Spliceosome Regulation Of Mitochondrion Organization Centriole Replication Membrane Organization Gene Expression Protein Transport Centriole Assembly Establishment Of Protein Localization Epidermal Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Centrosome Duplication ERBB Signaling Pathway Positive Regulation Of Transport Substantia Nigra Development Regulation Of Intracellular Transport Intrinsic Apoptotic Signaling Pathway Nervous System Development Positive Regulation Of Apoptotic Signaling Pathway MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Neural Nucleus Development Intracellular Protein Transport Centrosome Cycle Protein Localization Positive Regulation Of Intracellular Transport Apoptotic Process Establishment Of Localization In Cell Developmental Process Mitochondrial Translational Elongation Mitochondrial Translational Initiation Mitochondrial Translational Termination Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Programmed Cell Death Intracellular Transport Regulation Of Cellular Localization Cell Death Death Anatomical Structure Development Mitochondrial Translation System Development Midbrain Development Golgi Reassembly Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity RNA Splicing	Negative Regulation Of Translation Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of CAMP Catabolic Process Mast Cell Secretory Granule Organization Regulation Of Neuron Differentiation Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Ion Homeostasis Regulation Of Cell Differentiation IRES-dependent Translational Initiation Cap-independent Translational Initiation Regulation Of Neurogenesis Endosome Transport Via Multivesicular Body Sorting Pathway Circadian Regulation Of Translation Defense Response To Bacterium Negative Regulation Of Oxidative Stress-induced Neuron Death Bergmann Glial Cell Differentiation Negative Regulation Of Vasodilation Secretion Of Lysosomal Enzymes Protein Ufmylation Negative Regulation Of Translation In Response To Stress Regulation Of Cell Development Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Protein Homooligomerization Positive Regulation Of Gastrulation Phospholipid Homeostasis Regulation Of Gene Expression Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cytoplasmic Translational Initiation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Mitochondrial Depolarization Opsonization Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Phagocytosis Regulation Of Translation Cell Differentiation Central Nervous System Development Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Superoxide Anion Generation Regulation Of Interleukin-8 Secretion Regulation Of Cellular Localization Rhythmic Process Regulation Of Metabolic Process Cytoplasmic Translation Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Translation In Response To Stress Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Tagcloud ?		ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa machado park2 parkin parkinsonism pn polg1 premutation rakeb tremor
Tagcloud (Difference) ?		ataxin atp13a2 atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa machado park2 parkin parkinsonism pn polg1 premutation rakeb tremor
Tagcloud (Intersection) ?