PRAF2 and CCR5

Number of citations of the paper that reports this interaction (PMID 15757671)
8

Data Source:
HPRD (in vivo, two hybrid)

		PRAF2	CCR5
Gene Name		PRA1 domain family, member 2	chemokine (C-C motif) receptor 5 (gene/pseudogene)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Membrane Integral Component Of Membrane	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function		Actin Binding Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Protein Transport L-glutamate Transport	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Viral Process Calcium-mediated Signaling Signaling Entry Into Host Cell Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR HIV Infection Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Early Phase of HIV Life Cycle GPCR downstream signaling HIV Life Cycle Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events Binding and entry of HIV virion
Drugs			Maraviroc
Diseases
GWAS			Celiac disease ( 20190752)
Protein-Protein Interactions		2 interactors: ARL6IP5 CCR5	41 interactors: ADRBK1 ADRBK2 AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B STAT1 STAT3 STAT5A TXK
Entrez ID		11230	1234
HPRD ID		06596	03223
Ensembl ID		ENSG00000243279	ENSG00000160791
Uniprot IDs		O60831	A0A502 P51681 Q38L21
PDB IDs			1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2RLL 2RRS 4MBS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Mitochondrial Membrane Potential Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Sarcoplasmic Reticulum Calcium Ion Transport Negative Regulation Of Membrane Potential Dendritic Cell Chemotaxis Response To Cholesterol Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Dendritic Cell Migration L-glutamate Transport Regulation Of Mitochondrial Membrane Potential Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Entry Into Host Cell Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Cellular Defense Response Chemokine-mediated Signaling Pathway Ion Transport Intracellular Signal Transduction Dicarboxylic Acid Transport Calcium-mediated Signaling Interaction With Host Leukocyte Chemotaxis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Second-messenger-mediated Signaling Positive Regulation Of Peptidase Activity Cellular Response To Lipopolysaccharide Positive Regulation Of Cytosolic Calcium Ion Concentration Amino Acid Transport Cellular Response To Molecule Of Bacterial Origin Regulation Of Ion Homeostasis Cell Chemotaxis	Response To Stress Cell Chemotaxis Defense Response Immune Response Immune System Process Cellular Response To Stimulus Inflammatory Response Cell Migration Cell Motility Response To Stimulus Response To External Stimulus Signaling Locomotion Cell Communication Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Signal Transduction Regulation Of Cell Proliferation Chemotaxis Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Eosinophil Chemotaxis Eosinophil Migration Cellular Metal Ion Homeostasis Cell Activation Cellular Cation Homeostasis Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Natural Killer Cell Chemotaxis Cellular Chemical Homeostasis Regulation Of Signal Transduction Regulation Of Signaling Chemical Homeostasis Response To Cytokine Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Leukocyte Chemotaxis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Granulocyte Chemotaxis Cellular Response To Growth Hormone Stimulus
Tagcloud ?			7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Difference) ?			7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Intersection) ?