CHEK2 and PPP2R2A

Number of citations of the paper that reports this interaction (PMID 15380617)
16

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CHEK2	PPP2R2A
Gene Name		checkpoint kinase 2	protein phosphatase 2, regulatory subunit B, alpha
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleoplasm Golgi Apparatus PML Body	Protein Phosphatase Type 2A Complex Nucleoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Type 2A Regulator Activity
	Biological Process	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Cellular Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization Cell Division Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Spindle Assembly Replicative Senescence	G2/M Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Mitotic Cell Cycle Protein Dephosphorylation Mitotic Nuclear Envelope Reassembly Signal Transduction Gene Expression Response To Morphine Regulation Of Catalytic Activity
Pathways			Nonsense-Mediated Decay (NMD) G1 Phase G2/M Transition Mitotic Anaphase Cell Cycle, Mitotic M Phase Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Cyclin D associated events in G1 Cyclin A/B1 associated events during G2/M transition Nuclear Envelope Reassembly Initiation of Nuclear Envelope Reformation Mitotic G2-G2/M phases Mitotic G1-G1/S phases Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Vertical cup-disc ratio ( 20548946)	Height ( 23563607)
Protein-Protein Interactions		47 interactors: AATF APP ARHGAP1 ASF1A ATM ATR BRCA1 BRCA2 CDC25A CDC25C DAPK3 DBF4 E2F1 ELAVL1 ERCC6 FOXM1 KPNA2 LATS2 MDC1 MDM2 MDM4 MRC1 MSH2 MUS81 NBN NR4A1 PLK1 PLK3 POLR2L PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RAD9A RCHY1 REV3L RNF8 SRPK1 STRAP TP53 TSSK1B VHL	12 interactors: ATR CHEK2 GRIN1 GRIN2D MTOR NDRG1 PPP2CA PPP2R1A PPP2R1B RRN3 STRN3 TGFBR1
Entrez ID		11200	5520
HPRD ID		05084	09223
Ensembl ID		ENSG00000183765	ENSG00000221914
Uniprot IDs		O96017	P63151
PDB IDs		1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK	3DW8
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus Cell Cycle Process Cellular Response To Stress Cell Cycle Regulation Of Cell Cycle Mitotic Cell Cycle Process DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle DNA Metabolic Process Cell Cycle Checkpoint Response To Stress Signal Transduction By P53 Class Mediator DNA Repair Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Response To Stimulus Mitotic Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Radiation Negative Regulation Of Cell Cycle Apoptotic Process Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Programmed Cell Death Mitotic DNA Damage Checkpoint Regulation Of Protein Metabolic Process Double-strand Break Repair Mitotic DNA Integrity Checkpoint Cell Death Death Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Response To Abiotic Stimulus Signal Transduction DNA Recombination Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Signaling Nucleobase-containing Compound Metabolic Process Cell Communication Double-strand Break Repair Via Homologous Recombination Recombinational Repair	Regulation Of DNA Replication Regulation Of Signaling Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Mitotic Nuclear Envelope Reassembly Regulation Of Signal Transduction Nuclear Envelope Reassembly Positive Regulation Of Transcription, DNA-templated Peptidyl-serine Phosphorylation Nucleus Organization Replicative Senescence Positive Regulation Of Macromolecule Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Gene Expression Double-strand Break Repair Negative Regulation Of JAK-STAT Cascade Positive Regulation Of Cellular Biosynthetic Process Apoptotic Process Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Startle Response Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Process Regulation Of Intracellular Signal Transduction Cell Death Regulation Of Cellular Response To Heat Death Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Fibroblast Growth Factor Negative Regulation Of Signal Transduction Inactivation Of MAPK Activity Cell Development Response To Abiotic Stimulus Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intracellular Signal Transduction Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Regulation Of Cellular Component Organization Negative Regulation Of Signaling Positive Regulation Of Cell Death Developmental Process Synaptic Transmission, Glutamatergic
Tagcloud ?		alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	22q13 alterations analyzing brca1 candidates computational developments drive driver estimates estimating generations genomes genomic identifies instability lineage mutator mutators neutral passenger passengers prkdc somatic take technologies throughput timing tumorigenesis
Tagcloud (Difference) ?		alleles atm brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	22q13 alterations analyzing candidates computational developments drive driver estimates estimating generations genomes genomic identifies instability lineage mutator mutators neutral passenger passengers prkdc somatic take technologies throughput timing tumorigenesis
Tagcloud (Intersection) ?		brca1