NISCH and IRS4

Number of citations of the paper that reports this interaction (PMID 11912194)
7

Data Source:
HPRD (in vivo)

		NISCH	IRS4
Gene Name		nischarin	insulin receptor substrate 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Cytosol Plasma Membrane Membrane Recycling Endosome	Cytosol Plasma Membrane
	Molecular Function	Integrin Binding Protein Binding G-protein Coupled Amine Receptor Activity Phosphatidylinositol Binding Identical Protein Binding	Signal Transducer Activity SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Glucose Metabolic Process Apoptotic Process G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Pressure Rac Protein Signal Transduction Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Norepinephrine Secretion	Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Lipid Metabolic Process
Pathways			IRS-related events triggered by IGF1R Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IGF1R signaling cascade
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Waist-hip ratio ( 20935629)
Protein-Protein Interactions		3 interactors: AR IRS4 ITGA5	17 interactors: CRK CRKL EGFR ERBB2 GRB2 IGF1R MTNR1A MTNR1B NISCH PIK3CA PIK3R1 PRKCZ PTPN11 PTPN6 SOCS6 SOCS7 YWHAG
Entrez ID		11188	8471
HPRD ID		11391	04620
Ensembl ID		ENSG00000010322	ENSG00000133124
Uniprot IDs		Q9Y2I1	O14654
PDB IDs		3P0C
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Integrin Biosynthetic Process Positive Regulation Of Integrin Biosynthetic Process Regulation Of Integrin Biosynthetic Process Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Transcription From RNA Polymerase III Promoter Wound Healing, Spreading Of Epidermal Cells Cell Adhesion Mediated By Integrin Regulation Of Signal Transduction Cellular Response To Hormone Stimulus Negative Regulation Of Anoikis Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Anoikis Regulation Of Signaling Heterotypic Cell-cell Adhesion Regulation Of Transcription From RNA Polymerase III Promoter Positive Regulation Of Phosphorylation Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Androgen Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Hormone Endodermal Cell Differentiation Wound Healing, Spreading Of Cells Negative Regulation Of Cell Death Regulation Of Establishment Of Protein Localization To Plasma Membrane Cell-substrate Junction Assembly Regulation Of Protein Localization To Plasma Membrane Endoderm Formation Morphogenesis Of An Epithelial Sheet	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Peptide Cellular Response To Insulin Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Insulin Receptor Signaling Pathway Cellular Response To Hormone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Insulin Response To Peptide Hormone Regulation Of Phosphorylation Response To Peptide Regulation Of Protein Kinase Activity Response To Organonitrogen Compound Response To Hormone Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Signaling Regulation Of T Cell Activation Signal Transduction Response To Organic Substance Signaling Cell Communication Regulation Of Cell-cell Adhesion Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Response To Growth Factor Regulation Of Lymphocyte Activation Regulation Of MAPK Cascade Regulation Of Catalytic Activity Regulation Of Cell Activation Fc Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process T Cell Costimulation Regulation Of Immune Response
Tagcloud ?		23b 27b antitumor augmented biologic cascade correlates delivered engineered erbb2 feedback intraperitoneally inversely mir mirnas neu noncoding notably nucleotides relevance repressed restored rnas substantially suppress suppressing underscoring xenograft	arg35 arhg5 cbl cblb del digested downscaled doxycycline dyn2 errfi flp hek293 hsp71 hsp7c input l747 optimisation pc9 ptpra purifications quantities retroviral s752 sos1 sos2 tagged tap usb3b wipf2
Tagcloud (Difference) ?		23b 27b antitumor augmented biologic cascade correlates delivered engineered erbb2 feedback intraperitoneally inversely mir mirnas neu noncoding notably nucleotides relevance repressed restored rnas substantially suppress suppressing underscoring xenograft	arg35 arhg5 cbl cblb del digested downscaled doxycycline dyn2 errfi flp hek293 hsp71 hsp7c input l747 optimisation pc9 ptpra purifications quantities retroviral s752 sos1 sos2 tagged tap usb3b wipf2
Tagcloud (Intersection) ?