MAP4K1 and DAPP1

Number of citations of the paper that reports this interaction (PMID 14563325)
15

Data Source:
HPRD (in vivo, in vitro)

		MAP4K1	DAPP1
Gene Name		mitogen-activated protein kinase kinase kinase kinase 1	dual adaptor of phosphotyrosine and 3-phosphoinositides
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane	Cytosol Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity	Phospholipid Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Activation Of MAPKKK Activity Protein Phosphorylation Response To Stress Activation Of JUN Kinase Activity Cell Proliferation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation	Protein Dephosphorylation Signal Transduction
Pathways			Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs			Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ABL1 BLNK CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 SHC1 SYK TMEM101	12 interactors: BTK ERBB3 FCHSD2 HSD3B7 HSPA1A LCK LYN MAP4K1 PLCG1 PLCG2 RPL23 SRC
Entrez ID		11184	27071
HPRD ID		03583	05773
Ensembl ID		ENSG00000104814	ENSG00000070190
Uniprot IDs		Q92918	B4DW38 Q9UN19
PDB IDs			1FAO 1FB8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorylation Regulation Of Immune System Process Regulation Of Protein Kinase Activity Fc-epsilon Receptor Signaling Pathway Signal Transduction Antigen Receptor-mediated Signaling Pathway Regulation Of Signal Transduction Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Innate Immune Response Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Signaling Regulation Of MAPK Cascade Regulation Of Immune Response Cell Communication Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Cell Activation Immune Response Positive Regulation Of Protein Phosphorylation Defense Response Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Positive Regulation Of Phosphorylation Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Signal Transduction By Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Kinase Activity Platelet Activation Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process MAPK Cascade Cell Surface Receptor Signaling Pathway	Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Antigen Receptor-mediated Signaling Pathway Regulation Of Ion Homeostasis Regulation Of Immune System Process Innate Immune Response Protein Autophosphorylation Regulation Of Immune Response Positive Regulation Of Immune System Process Viral Process Peptidyl-tyrosine Phosphorylation Wound Healing Positive Regulation Of Immune Response Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Positive Regulation Of Protein Phosphorylation Immune Response Defense Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Intracellular Signal Transduction Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Hemostasis Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Stress Regulation Of Cell Death Platelet Activation Response To Fibroblast Growth Factor Positive Regulation Of Kinase Activity Peptidyl-amino Acid Modification Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Neurotrophin Signaling Pathway Leukocyte Migration Positive Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Regulation Of Body Fluid Levels
Tagcloud ?		accelerated called cd4 chip concordantly contributing enhancer enrichment erythematosus h3k27me3 homolog hpk1 hyper ifngamma igg jmjd3 jumonji knock lupus medications overactivation overexpressing overstimulation plasmid reactivity sle striking trimethylation zeste	abat accuracy biomarkers bisulfite cloning diagnosis differential downregulated draft fadd hematologic hypermethylated hypermethylation lrrfip1 mds methylation microarray myelodysplastic noninvasive patterns plbd1 profiles refined screened sequencing smpd3 specificity validate validation
Tagcloud (Difference) ?		accelerated called cd4 chip concordantly contributing enhancer enrichment erythematosus h3k27me3 homolog hpk1 hyper ifngamma igg jmjd3 jumonji knock lupus medications overactivation overexpressing overstimulation plasmid reactivity sle striking trimethylation zeste	abat accuracy biomarkers bisulfite cloning diagnosis differential downregulated draft fadd hematologic hypermethylated hypermethylation lrrfip1 mds methylation microarray myelodysplastic noninvasive patterns plbd1 profiles refined screened sequencing smpd3 specificity validate validation
Tagcloud (Intersection) ?