CHGA and PLG

Number of citations of the paper that reports this interaction (PMID 11342539)
20

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		CHGA	PLG
Gene Name		chromogranin A (parathyroid secretory protein 1)	plasminogen
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Secretory Granule Transport Vesicle Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Platelet Alpha Granule Lumen Extrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function		Serine-type Endopeptidase Activity Receptor Binding Protein Binding Serine-type Peptidase Activity Protein Domain Specific Binding Apolipoprotein Binding
	Biological Process	Regulation Of Blood Pressure	Platelet Degranulation Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Tissue Regeneration Fibrinolysis Cellular Protein Metabolic Process Myoblast Differentiation Muscle Cell Cellular Homeostasis Tissue Remodeling Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Fibrinolysis Positive Regulation Of Fibrinolysis Transmembrane Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Blood Vessel Development Mononuclear Cell Migration Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways			Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Dissolution of Fibrin Clot Platelet degranulation Degradation of the extracellular matrix Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation Orphan transporters
Drugs			Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic Acid Aminocaproic Acid Bicine Aprotinin
Diseases
GWAS			Aging ( 22773346) Lp (a) levels ( 21900290)
Protein-Protein Interactions		6 interactors: CDC37 NEK2 PFDN1 PLG SCG3 UBC	61 interactors: ACTB AMOT ANXA2 APOH ATP5B C7 CDCP1 CHGA CLEC3B CP CPB2 CXCL2 CYFIP2 ENO1 EP300 F10 F2R F2RL1 F3 FN1 HMGB1 HRG HSPA1A HSPB1 HSPD1 IGF2 IGFBP3 KLK3 KNG1 LAMA1 LAMA3 LAMA5 MAPK14 MEP1A MMP3 MMP7 MMP9 NGF PAPPA PCOLCE PLAT PLAU PRDX4 PRNP RAP2A RBBP6 RUVBL1 S100A10 SERPINB13 SERPINB6 SERPINC1 SERPINE1 SERPINF2 SERPING1 SERPINI1 SMAD3 SMAD4 SPARC TFPI2 THBS1 YTHDC1
Entrez ID		1113	5340
HPRD ID		07170	01417
Ensembl ID		ENSG00000100604	ENSG00000122194
Uniprot IDs		G5E968 P10645 Q86T07	P00747 Q5TEH5
PDB IDs		1LV4	1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2KNF 2L0S 2PK4 3UIR 4A5T 4DCB 4DUR 4DUU 5HPG
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Centriole-centriole Cohesion Cellular Protein Catabolic Process Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Cell Activation Establishment Of Localization In Cell Mononuclear Cell Migration Regulation Of Centriole-centriole Cohesion Cellular Macromolecule Catabolic Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Platelet Activation Cellular Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Mitotic Centrosome Separation Cellular Localization Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Folding Negative Regulation Of Fibrinolysis Viral Protein Processing Exocytosis Cell Cycle Protein Metabolic Process Regulation Of Fibrinolysis Centrosome Separation Regulation Of Mitotic Cell Cycle Blood Coagulation Proteolysis Hemostasis Mitotic Spindle Assembly Trophoblast Giant Cell Differentiation Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Notch Receptor Processing Regulation Of Attachment Of Spindle Microtubules To Kinetochore Virion Assembly Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Secretion By Cell In Utero Embryonic Development Modification-dependent Protein Catabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway	Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Protein Metabolic Process Negative Regulation Of Wound Healing Regulation Of Peptidase Activity Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Cell Migration Regulation Of Endopeptidase Activity Regulation Of Cell Motility Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stress Regulation Of Fibrinolysis Platelet Activation Regulation Of Protein Processing Positive Regulation Of Blood Coagulation Negative Regulation Of Fibrinolysis Cell Activation Positive Regulation Of Coagulation Platelet Degranulation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Proliferation Response To External Stimulus Negative Regulation Of Protein Processing Negative Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Defense Response Negative Regulation Of Endopeptidase Activity Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Peptidase Activity Zymogen Activation Negative Regulation Of Hydrolase Activity
Tagcloud ?		antibodies antigenic autoantibodies bdc2 cd4 chromogranin employed epitope extension flanking fragments g7 humoral immuno immunostaining islet kcvlevisd molecule nod overlap pancreatic peptide peptides register sections sequence sera titers truncation	1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed
Tagcloud (Difference) ?		antibodies antigenic autoantibodies bdc2 cd4 chromogranin employed epitope extension flanking fragments g7 humoral immuno immunostaining islet kcvlevisd molecule nod overlap pancreatic peptide peptides register sections sequence sera titers truncation	1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed
Tagcloud (Intersection) ?