RAB10 and MTNR1A

Number of citations of the paper that reports this interaction (PMID 17215244)
14

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RAB10	MTNR1A
Gene Name		RAB10, member RAS oncogene family	melatonin receptor 1A
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Exocyst Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Plasma Membrane Focal Adhesion Endosome Membrane Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Insulin-responsive Compartment Recycling Endosome Recycling Endosome Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network Primary Cilium	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	GTPase Activity GTP Binding GDP Binding Myosin V Binding	Protein Binding Melatonin Receptor Activity Hormone Binding Organic Cyclic Compound Binding
	Biological Process	Intracellular Protein Transport Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Axonogenesis Protein Secretion Vesicle-mediated Transport Endosomal Transport Regulation Of Exocytosis Antigen Processing And Presentation Polarized Epithelial Cell Differentiation Rab Protein Signal Transduction Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Establishment Of Neuroblast Polarity Membrane Organization Basolateral Protein Localization Endoplasmic Reticulum Tubular Network Organization Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Membrane	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Mating Behavior Circadian Rhythm Positive Regulation Of CGMP Biosynthetic Process
Pathways		Translocation of GLUT4 to the plasma membrane	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Ramelteon Melatonin Agomelatine
Diseases
GWAS		Immune response to smallpox vaccine (IL-6) ( 22542470) Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000) Metabolite levels (HVA/MHPG ratio) ( 23319000)	Obesity ( 21552555)
Protein-Protein Interactions		9 interactors: APP ENOPH1 EVI5L MICAL1 MTNR1A OPTN PPBP RIMS1 SEPT9	26 interactors: CALR CANX CNP DPM1 EEF1G FLNA GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 LRRC59 MTNR1B PDIA6 PGRMC1 RAB10 RAC1 RAP1A TMEM33 VAPB
Entrez ID		10890	4543
HPRD ID		06692	02812
Ensembl ID		ENSG00000084733	ENSG00000168412
Uniprot IDs		P61026	P48039
PDB IDs
Enriched GO Terms of Interacting Partners?		Mating Behavior Mating Exocytosis Platelet Degranulation Secretion By Cell Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Negative Regulation Of Cilium Assembly Vesicle-mediated Transport Secretion Negative Regulation Of Receptor Recycling Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Defense Response To Bacterium Platelet Activation Axon Choice Point Recognition Golgi Ribbon Formation Sulfur Oxidation	Platelet Activation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Signaling Cell Communication Response To Stimulus G-protein Coupled Receptor Signaling Pathway Signal Transduction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Organic Substance Positive Regulation Of Nuclease Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Kinase Activity Vesicle-mediated Transport Positive Regulation Of Transferase Activity Response To Stress Synaptic Transmission Cell-cell Signaling Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Stimulus Cellular Response To Topologically Incorrect Protein Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Dopamine Receptor Signaling Pathway Substantia Nigra Development Cellular Response To Organic Substance Response To Unfolded Protein Regulation Of Kinase Activity Membrane Organization Positive Regulation Of Phosphorylation Response To Endoplasmic Reticulum Stress Cell Surface Receptor Signaling Pathway Neural Nucleus Development Positive Regulation Of Protein Modification Process Ras Protein Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Response To Peptide Hormone Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		a8 a9 aldehyde aldh3a1 beta4 biglycan chymase cma1 conjunctiva conjunctival fibrovascular gelsolin genechip immunofluorescent infiltrates itraq member1 pterygium s100 s100a8 s100a9 sawdust serpin serpina1 stringent thymosin uninvolved vim wing
Tagcloud (Difference) ?		a8 a9 aldehyde aldh3a1 beta4 biglycan chymase cma1 conjunctiva conjunctival fibrovascular gelsolin genechip immunofluorescent infiltrates itraq member1 pterygium s100 s100a8 s100a9 sawdust serpin serpina1 stringent thymosin uninvolved vim wing
Tagcloud (Intersection) ?