SRSF10 and SNRNP70

Number of citations of the paper that reports this interaction (PMID 14765198)
47

Data Source:
HPRD (in vivo, in vitro)

		SRSF10	SNRNP70
Gene Name		serine/arginine-rich splicing factor 10	small nuclear ribonucleoprotein 70kDa (U1)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Poly(A) RNA Binding RS Domain Binding Unfolded Protein Binding	Nucleotide Binding RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Regulation Of Transcription, DNA-templated MRNA Splice Site Selection MRNA Export From Nucleus Cytoplasmic Transport Negative Regulation Of MRNA Splicing, Via Spliceosome	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		10 interactors: CSNK2A1 FUS SNRNP70 SREK1 SRSF1 SRSF4 TRA2A TRA2B YWHAB YWHAG	43 interactors: APP ARSF CDKL3 CEP63 CHERP CLK2 CRP CSNK2A1 CTDP1 DDX17 GEMIN2 HNRNPA2B1 HTATSF1 IL32 IL7R LRP1 MYC NUDT21 PRKD2 PRMT5 PRPF40A RASGRF1 RELA RNF11 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SRPK1 SRPK2 SRSF1 SRSF10 SRSF2 TOP1 WBP4 ZRANB2
Entrez ID		10772	6625
HPRD ID		05562	01617
Ensembl ID		ENSG00000188529	ENSG00000104852
Uniprot IDs		O75494	P08621 Q9UFS1
PDB IDs			2L5I 2L5J 3CW1 3PGW
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of RNA Splicing Gene Expression RNA Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of RNA Splicing Cellular Nitrogen Compound Metabolic Process Termination Of RNA Polymerase II Transcription Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrion Organization MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing Regulation Of Mitochondrion Organization RNA 3'-end Processing Nuclear Export MRNA Transport RNA Transport RNA Localization MRNA 5'-splice Site Recognition Negative Regulation Of Protein Dephosphorylation Intracellular Transport Intrinsic Apoptotic Signaling Pathway Cellular Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Transport Regulation Of RNA Metabolic Process Negative Regulation Of Protein Metabolic Process Nucleocytoplasmic Transport Nuclear Transport Regulation Of Organelle Organization Response To Insulin Regulation Of Cellular Protein Metabolic Process Apoptotic Process	RNA Processing RNA Metabolic Process Gene Expression MRNA Processing RNA Splicing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Nitrogen Compound Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Complex Assembly Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Cellular Macromolecular Complex Assembly Mesonephros Development Spliceosomal Complex Assembly Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Cellular Metabolic Process Response To Growth Factor Kidney Epithelium Development Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Assembly Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of RNA Splicing Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Component Assembly Primary MiRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Cell Differentiation Regulation Of Metabolic Process Regulation Of Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway BMP Signaling Pathway Embryonic Pattern Specification Anatomical Structure Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of MRNA Processing
Tagcloud ?		antigens autoregulatory b10 correlates deaf1 deformed drive hek293t hyperglycemia inflammation isoform lnscs lymph mediate nod nodes plns pta ptas ptbp2 s961 scid splenocytes spliced splicing stromal t1d tolerance var1
Tagcloud (Difference) ?		antigens autoregulatory b10 correlates deaf1 deformed drive hek293t hyperglycemia inflammation isoform lnscs lymph mediate nod nodes plns pta ptas ptbp2 s961 scid splenocytes spliced splicing stromal t1d tolerance var1
Tagcloud (Intersection) ?