AP4B1 and AP4E1

Number of citations of the paper that reports this interaction (PMID 10436028)
54

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		AP4B1	AP4E1
Gene Name		adaptor-related protein complex 4, beta 1 subunit	adaptor-related protein complex 4, epsilon 1 subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Trans-Golgi Network Coated Pit Clathrin Adaptor Complex	Golgi Apparatus Coated Pit Membrane Coat
	Molecular Function	Transporter Activity Protein Transporter Activity
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport	Intracellular Protein Transport Vesicle-mediated Transport
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: AP4E1 AP4M1 BUB1 BUB1B ZNF576	3 interactors: AP4B1 AP4S1 ARF1
Entrez ID		10717	23431
HPRD ID		06259	06258
Ensembl ID		ENSG00000134262	ENSG00000081014
Uniprot IDs		B4DTG3 Q9Y6B7	B4DM48 Q9UPM8
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Division Cellular Protein Localization Mitotic Nuclear Division Metaphase/anaphase Transition Of Mitotic Cell Cycle Protein Localization To Kinetochore Negative Regulation Of Proteolysis Protein Localization To Chromosome, Centromeric Region Negative Regulation Of Protein Processing Regulation Of Protein Catabolic Process Regulation Of Protein Processing Regulation Of Mitotic Cell Cycle Cell Division Negative Regulation Of Cell Cycle Regulation Of Sister Chromatid Cohesion Golgi To Endosome Transport Regulation Of Cell Cycle Process Protein Localization Protein Localization To Chromosome Regulation Of Proteolysis Mitotic Cell Cycle Process Cell Proliferation Cellular Localization Mitotic Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle	Protein Transport Establishment Of Protein Localization Protein Localization COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Long Term Synaptic Depression Cellular Copper Ion Homeostasis Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization Copper Ion Homeostasis Regulation Of Actin Nucleation Regulation Of Defense Response To Virus By Virus Vesicle Targeting, To, From Or Within Golgi Regulation Of Receptor Internalization Retrograde Vesicle-mediated Transport, Golgi To ER Vesicle Targeting Localization Within Membrane Negative Regulation Of Synaptic Transmission Transport Membrane Budding Regulation Of Defense Response To Virus Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Intracellular Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Phosphatidylinositol Biosynthetic Process
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