DCTN6 and NCOA3

Number of citations of the paper that reports this interaction (PMID 21577200)
17

Data Source:
BioGRID (two hybrid)

		DCTN6	NCOA3
Gene Name		dynactin 6	nuclear receptor coactivator 3
Image
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Centrosome Cytosol Dynactin Complex	Nucleus Nucleoplasm Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Dynein Binding	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Signal Transducer Activity Protein Binding Ligand-dependent Nuclear Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein N-terminus Binding Androgen Receptor Binding
	Biological Process	Mitotic Spindle Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	Transcription, DNA-templated Positive Regulation Of Gene Expression Histone Acetylation Androgen Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Cellular Response To Hormone Stimulus Multicellular Organism Growth Receptor Transactivation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Developmental Growth Vagina Development Labyrinthine Layer Morphogenesis Mammary Gland Branching Involved In Thelarche Regulation Of RNA Biosynthetic Process
Pathways		MHC class II antigen presentation Adaptive Immune System	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Response to treatment for acute lymphoblastic leukemia ( 19176441)
Protein-Protein Interactions		4 interactors: APP CDK1 NCOA3 RPSA	77 interactors: ABL1 ANKRD11 AR ARNT2 ATAD2 BMP6 BMP7 BRCA1 BRE CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B HIST3H3 HIST4H4 IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SMARCE1 SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ
Entrez ID		10671	8202
HPRD ID		09907	03570
Ensembl ID		ENSG00000104671	ENSG00000124151
Uniprot IDs		O00399	Q0IIN7 Q59EE8 Q9Y6Q9
PDB IDs		3TV0	1KBH 3L3X 3L3Z
Enriched GO Terms of Interacting Partners?		RNA 3'-end Processing Positive Regulation Of Mitotic Cell Cycle Regulation Of Receptor Activity Pronuclear Fusion RRNA Export From Nucleus Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Synaptic Growth At Neuromuscular Junction Intracellular Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Reproductive Process Receptor Transactivation RRNA Transport Collateral Sprouting Axon Midline Choice Point Recognition Developmental Growth Positive Regulation Of Cell Cycle Regulation Of Developmental Growth Positive Regulation Of Proteolysis Mammary Gland Branching Involved In Thelarche Smooth Endoplasmic Reticulum Calcium Ion Homeostasis RRNA 3'-end Processing Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Axon Choice Point Recognition Regulation Of Schwann Cell Differentiation Regulation Of Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Neuron Remodeling Protein Localization To Kinetochore Axon Guidance Histone Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Ribosomal Small Subunit Assembly Protein Localization To Chromosome, Centromeric Region Development Of Secondary Female Sexual Characteristics Response To Oxidative Stress Positive Regulation Of Protein Import Into Nucleus, Translocation Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Cellular Component Assembly Cellular Nitrogen Compound Metabolic Process Development Of Secondary Sexual Characteristics Growth Vagina Development Protein Localization To Organelle	Steroid Hormone Mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Response To Steroid Hormone Response To Lipid Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Lipid Regulation Of Gene Expression Response To Hormone Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Cellular Response To Organic Cyclic Compound Cellular Response To Organic Substance Transcription, DNA-templated Response To Organic Substance RNA Biosynthetic Process Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Gene Expression Negative Regulation Of RNA Biosynthetic Process Signaling Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cell Communication Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process
Tagcloud ?			acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy meis1 menin mll1 moz myst3 overlap progenitor progenitors proliferative tale tif2 translocations
Tagcloud (Difference) ?			acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes kat6a localizes lymphoma maintain maintaining maintains malignancy meis1 menin mll1 moz myst3 overlap progenitor progenitors proliferative tale tif2 translocations
Tagcloud (Intersection) ?