PAIP1 and EIF4A1

Number of citations of the paper that reports this interaction (PMID 9548260)
110

Data Source:
HPRD (in vivo, in vitro)

		PAIP1	EIF4A1
Gene Name		poly(A) binding protein interacting protein 1	eukaryotic translation initiation factor 4A1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Protein Binding Translation Activator Activity	RNA Cap Binding Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translational Initiation Gene Expression Positive Regulation Of Translation MRNA Stabilization	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Gene Expression Viral Process Cytokine-mediated Signaling Pathway Organ Regeneration Cellular Protein Metabolic Process
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay	Translation initiation complex formation Translation Deadenylation of mRNA ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system L13a-mediated translational silencing of Ceruloplasmin expression Antiviral mechanism by IFN-stimulated genes Deadenylation-dependent mRNA decay Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: EIF4A1 PABPC1 UBR5 WWP2	10 interactors: EIF4G1 EIF4G2 EIF4G3 LIG4 LPPR4 MAPK6 PAIP1 PRMT1 UCHL5 UPF2
Entrez ID		10605	1973
HPRD ID		05539	04030
Ensembl ID		ENSG00000172239	ENSG00000161960
Uniprot IDs		Q9H074	P60842
PDB IDs		1JH4 3NTW 3RK6	2G9N 2ZU6 3EIQ
Enriched GO Terms of Interacting Partners?		Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process MRNA 3'-end Processing RNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Protein Polyubiquitination RNA Catabolic Process Negative Regulation Of Histone H2A K63-linked Ubiquitination Translational Initiation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Histone Ubiquitination Negative Regulation Of Protein K63-linked Ubiquitination Progesterone Receptor Signaling Pathway Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair Cellular Protein Metabolic Process Negative Regulation Of DNA Repair Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Processing Positive Regulation Of Protein Import Into Nucleus, Translocation Aromatic Compound Catabolic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of MRNA 3'-end Processing MRNA Metabolic Process Protein Metabolic Process Regulation Of Protein Import Into Nucleus, Translocation Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process RNA Processing Protein Ubiquitination Positive Regulation Of MRNA Catabolic Process Regulation Of Catenin Import Into Nucleus Protein Modification By Small Protein Conjugation Protein Catabolic Process Regulation Of Protein Transport MRNA Stabilization Regulation Of Double-strand Break Repair Translation Regulation Of Establishment Of Protein Localization Regulation Of Potassium Ion Transmembrane Transporter Activity	Translational Initiation Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Catabolic Process Translation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Metabolic Process Cellular Macromolecule Catabolic Process DNA Ligation Involved In DNA Recombination Cellular Protein Metabolic Process MRNA 3'-end Processing Regulation Of Cellular Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytokine-mediated Signaling Pathway Aromatic Compound Catabolic Process RNA 3'-end Processing Regulation Of Protein Metabolic Process Gene Expression MRNA Metabolic Process Viral Process Cellular Macromolecule Biosynthetic Process Cellular Response To Cytokine Stimulus Macromolecule Biosynthetic Process Negative Regulation Of Megakaryocyte Differentiation Protein Metabolic Process Lagging Strand Elongation Pro-B Cell Differentiation Response To Cytokine Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Establishment Of Integrated Proviral Latency Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Immunoglobulin V(D)J Recombination Establishment Of Viral Latency DNA Recombination T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair Metabolic Process Catabolic Process Lymphoid Progenitor Cell Differentiation Peptidyl-arginine N-methylation Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Histone H4-R3 Methylation RNA Metabolic Process DNA Ligation Cellular Response To Stimulus
Tagcloud ?		4g abrogated consequent eif3 eif3f eif3g eif4g enhancement eukaryotic initiation interacting interaction mtorc1 pabp phosphorylate phosphorylates poly pp242 rapamycin ribosomal s6 s6k s6k1 shrna simultaneous stimulate stimulates tail translation	classes constituents cycling cyclins dexd dysregulation eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 pdcd4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Difference) ?		4g abrogated consequent eif3 eif3f eif3g eif4g enhancement eukaryotic initiation interacting interaction mtorc1 pabp phosphorylate phosphorylates poly pp242 rapamycin ribosomal s6 s6k s6k1 shrna simultaneous stimulate stimulates tail translation	classes constituents cycling cyclins dexd dysregulation eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 pdcd4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Intersection) ?