SH2B2 and EPOR

Number of citations of the paper that reports this interaction (PMID 10374881)
17

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		SH2B2	EPOR
Gene Name		SH2B adaptor protein 2	erythropoietin receptor
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane	Extracellular Region Integral Component Of Plasma Membrane
	Molecular Function	Signal Transducer Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding JAK Pathway Signal Transduction Adaptor Activity Identical Protein Binding	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	B-1 B Cell Homeostasis Signal Transduction Nervous System Development Blood Coagulation Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of JAK-STAT Cascade Regulation Of Ras Protein Signal Transduction Antigen Receptor-mediated Signaling Pathway Brown Fat Cell Differentiation	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Decidualization
Pathways		Signaling by SCF-KIT Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
Drugs			Darbepoetin alfa Epoetin alfa 3,5 DIBROMOTYROSINE Peginesatide
Diseases
GWAS
Protein-Protein Interactions		21 interactors: AKT1 ASB6 BTK CBL EPOR ERBB2 FYN GRB2 INSR JAK1 JAK2 JAK3 KIT LYN NTRK1 NTRK2 PDLIM7 SH2B1 SHC1 SORBS1 SYK	36 interactors: ATXN2L CBL CISH CRKL CSF2RB EPO GAB1 GAB2 GNAI1 GNB2L1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK SYP VAV1
Entrez ID		10603	2057
HPRD ID		16097	00587
Ensembl ID			ENSG00000187266
Uniprot IDs		O14492	P19235
PDB IDs		1Q2H	1CN4 1EBA 1EBP 1EER 1ERN 2JIX
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Protein Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Peptidyl-tyrosine Autophosphorylation Intracellular Signal Transduction Peptidyl-amino Acid Modification Positive Regulation Of Signal Transduction Response To Organic Substance Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Protein Phosphorylation Innate Immune Response Fc Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cell Proliferation Regulation Of Immune Response Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Peptide Signaling Neurotrophin TRK Receptor Signaling Pathway Defense Response Cell Communication Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Phosphorylation Response To Growth Factor Movement Of Cell Or Subcellular Component Response To Peptide Hormone Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signaling ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Locomotion Cell Activation Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Cell Activation Response To Peptide Response To Wounding Immune Response Regulation Of Immune System Process Cellular Response To Stimulus	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Response To Organic Substance Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Intracellular Signal Transduction Cellular Response To Peptide Regulation Of Kinase Activity Fc Receptor Signaling Pathway Response To Peptide Hormone Regulation Of Body Fluid Levels JAK-STAT Cascade Response To Peptide Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Blood Coagulation Regulation Of Immune System Process Hemostasis Innate Immune Response Defense Response Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Regulation Of Signaling Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Protein Kinase Activity ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Hormone Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Wounding Wound Healing Neurotrophin TRK Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Neurotrophin Signaling Pathway Regulation Of Intracellular Signal Transduction Signaling Cell Communication
Tagcloud ?		accordingly adaptor aps assembling called counteract dephosphorylation dimerization dimers hetero homo hyperphagia insects irs1 irs2 leptin obesity protecting protects psm sh2b1 sh2b1beta sh2b3 transgenes trka tyrosyl	actual agonist angstrom antagonist apart configuration crystal dimer efficiency erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit plasticity preformed recognition resolution spanning thought unliganded
Tagcloud (Difference) ?		accordingly adaptor aps assembling called counteract dephosphorylation dimerization dimers hetero homo hyperphagia insects irs1 irs2 leptin obesity protecting protects psm sh2b1 sh2b1beta sh2b3 transgenes trka tyrosyl	actual agonist angstrom antagonist apart configuration crystal dimer efficiency erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit plasticity preformed recognition resolution spanning thought unliganded
Tagcloud (Intersection) ?