CENPC and DAXX

Number of citations of the paper that reports this interaction (PMID 9645950)
31

Data Source:
HPRD (in vivo, two hybrid)

		CENPC	DAXX
Gene Name		centromere protein C	death-domain associated protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome, Centromeric Region Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol	Chromosome, Centromeric Region Heterochromatin Nucleus Nucleolus Cytoplasm Cytosol PML Body SWI/SNF Superfamily-type Complex
	Molecular Function	DNA Binding Centromeric DNA Binding	P53 Binding Transcription Corepressor Activity Receptor Signaling Protein Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Protein Kinase Activator Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Protein Homodimerization Activity Protein N-terminus Binding Androgen Receptor Binding
	Biological Process	Mitotic Cell Cycle Nucleosome Assembly Chromosome Segregation Mitotic Nuclear Division CENP-A Containing Nucleosome Assembly Cell Division Kinetochore Assembly	Mitotic Cytokinesis Positive Regulation Of Protein Phosphorylation Nucleosome Assembly Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Activation Of JUN Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Viral Process Androgen Receptor Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neuron Death Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: DAXX MAPK14 MDC1 SUMO2 TCEB1 UBTF	82 interactors: AIRE AR ATM ATRX BTBD6 CA12 CALCOCO2 CARD9 CARM1 CBS CDCA7L CENPC CFLAR CREBBP DAPK3 DMAP1 DNMT1 ESRRG ETS1 FAM9B FANCA FAS FASLG FTH1 GOLGA2 H3F3A HABP4 HBA1 HDAC1 HDAC2 HDAC3 HIPK1 HIPK2 HIPK3 HIST1H3C HIST1H4F HIST4H4 HSF1 HSPB1 MAP3K5 MCRS1 MDM2 MST1 MX1 MYH11 NECAB2 NR3C1 PARK7 PAX3 PAX5 PBXIP1 PLAGL1 PML PRMT1 RASSF1 RPL13 SENP2 SERBP1 SLC2A4 SLC9A1 SNW1 SPN SPOP SSX2IP STAT3 STUB1 SUMO1 TCF3 TCF7L2 TGFB1 TGFB2 TGFBR2 TNFRSF1A TP53 TP63 TP73 TRAF3 TRIM21 TSG101 UBE2I USP7 WHSC1L1
Entrez ID		1060	1616
HPRD ID		00315	04424
Ensembl ID		ENSG00000145241	ENSG00000204209
Uniprot IDs		Q03188 Q6PIR0	B4E1C1 F5ANJ6 F5ANJ7 Q53F85 Q9UER7
PDB IDs			2KQS 2KZS 2KZU 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process DNA-templated Transcription, Elongation Cellular Response To Stress P38MAPK Cascade Positive Regulation Of Metabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity DNA Damage Checkpoint Chromatin Remodeling Transcription, DNA-templated Positive Regulation Of MAP Kinase Activity Positive Regulation Of Brown Fat Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration RNA Biosynthetic Process MAPK Cascade Nucleobase-containing Compound Metabolic Process Cell Cycle Checkpoint Regulation Of Brown Fat Cell Differentiation Cell Cycle Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Cellular Nitrogen Compound Metabolic Process Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process 3'-UTR-mediated MRNA Stabilization Intra-S DNA Damage Checkpoint Positive Regulation Of Transcription From RNA Polymerase I Promoter Stress-induced Premature Senescence Positive Regulation Of Transcription, DNA-templated Cell Cycle Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Fusion Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Response To Muramyl Dipeptide Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of MAPK Cascade Positive Regulation Of Erythrocyte Differentiation Response To Stress Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion	Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Stress Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cell Death Regulation Of Signal Transduction Death Apoptotic Process Regulation Of Protein Metabolic Process Response To Organic Substance Positive Regulation Of Gene Expression Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Programmed Cell Death Gene Expression Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Signaling Transcription, DNA-templated Cellular Response To Stress Cellular Aromatic Compound Metabolic Process Chromatin Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Response To Stimulus Chromosome Organization Organelle Organization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle
Tagcloud ?			adaptor appear characterization convey death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit
Tagcloud (Difference) ?			adaptor appear characterization convey death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit
Tagcloud (Intersection) ?