SPTLC1 and SPTLC2

Number of citations of the paper that reports this interaction (PMID 10722674)
19

Data Source:
HPRD (in vitro, in vivo)

		SPTLC1	SPTLC2
Gene Name		serine palmitoyltransferase, long chain base subunit 1	serine palmitoyltransferase, long chain base subunit 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane Serine C-palmitoyltransferase Complex SPOTS Complex	Mitochondrion Endoplasmic Reticulum Membrane Integral Component Of Membrane Serine C-palmitoyltransferase Complex
	Molecular Function	Serine C-palmitoyltransferase Activity Protein Binding Pyridoxal Phosphate Binding	Serine C-palmitoyltransferase Activity Pyridoxal Phosphate Binding
	Biological Process	Sphingolipid Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Small Molecule Metabolic Process Sphinganine Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process	Sphingolipid Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Small Molecule Metabolic Process Sphinganine Biosynthetic Process Sphingosine Biosynthetic Process Ceramide Biosynthetic Process
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis	Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs		Pyridoxal Phosphate L-Serine	Pyridoxal Phosphate L-Serine
Diseases
GWAS		Bipolar disorder and schizophrenia ( 22688191)
Protein-Protein Interactions		2 interactors: ABCA1 SPTLC2	2 interactors: NOTCH3 SPTLC1
Entrez ID		10558	9517
HPRD ID		05754	05755
Ensembl ID		ENSG00000090054	ENSG00000100596
Uniprot IDs		O15269 Q6NUL7	O15270
PDB IDs
Enriched GO Terms of Interacting Partners?		Sphinganine Biosynthetic Process Alcohol Metabolic Process Sphinganine Metabolic Process Interleukin-1 Beta Secretion Sphingomyelin Biosynthetic Process Apolipoprotein A-I-mediated Signaling Pathway Sphingosine Biosynthetic Process Interleukin-1 Secretion Sphingoid Biosynthetic Process Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Platelet Dense Granule Organization Phospholipid Efflux Phagocytosis, Engulfment Sphingosine Metabolic Process Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Sphingomyelin Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cellular Response To Cholesterol Response To Laminar Fluid Shear Stress Membrane Invagination Reverse Cholesterol Transport Protein-lipid Complex Assembly Response To Lipoprotein Particle Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Positive Regulation Of Cholesterol Transport Cellular Lipid Metabolic Process Regulation Of Cholesterol Efflux Response To Cholesterol Cholesterol Efflux Regulation Of Cdc42 Protein Signal Transduction Cytokine Secretion Lipid Metabolic Process Response To Fluid Shear Stress Regulation Of Cholesterol Transport Secretory Granule Organization Regulation Of Macrophage Derived Foam Cell Differentiation Anion Homeostasis Ceramide Biosynthetic Process Lysosome Organization Regulation Of Lipid Storage Phospholipid Translocation Positive Regulation Of Lipid Transport Regulation Of Plasma Lipoprotein Particle Levels	Sphinganine Biosynthetic Process Sphinganine Metabolic Process Sphingomyelin Biosynthetic Process Sphingosine Biosynthetic Process Sphingoid Biosynthetic Process Glomerular Capillary Formation Sphingosine Metabolic Process Sphingomyelin Metabolic Process Glomerulus Morphogenesis Notch Receptor Processing Glomerulus Vasculature Development Ceramide Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Glomerulus Development Sphingolipid Biosynthetic Process Neuron Fate Commitment Ceramide Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Cellular Biogenic Amine Metabolic Process Notch Signaling Pathway Amine Metabolic Process Nephron Development Sphingolipid Metabolic Process Transcription Initiation From RNA Polymerase II Promoter
Tagcloud ?		2d autosomal axonal clustered decade defines drg ganglion harvested hereditary hsn hsns ig immunoblotting inheritance lymphoblasts neuropathies neuropathy palmitoyltransferase path perinucleus reductase route sensory subsets ubiquinol ultrastructural wrapped	a2 annexin attracted boyden cd74 cdk5 chamber chemotactic clues col11a1 f3 glioblastoma glioma gliomas gliotropism harbor histologically migrate mobile pd98057 proteomics prove reach rescovitine throughput timp tnfsf8 tropism u87
Tagcloud (Difference) ?		2d autosomal axonal clustered decade defines drg ganglion harvested hereditary hsn hsns ig immunoblotting inheritance lymphoblasts neuropathies neuropathy palmitoyltransferase path perinucleus reductase route sensory subsets ubiquinol ultrastructural wrapped	a2 annexin attracted boyden cd74 cdk5 chamber chemotactic clues col11a1 f3 glioblastoma glioma gliomas gliotropism harbor histologically migrate mobile pd98057 proteomics prove reach rescovitine throughput timp tnfsf8 tropism u87
Tagcloud (Intersection) ?