TM9SF1 and P2RX7

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TM9SF1	P2RX7
Gene Name		transmembrane 9 superfamily member 1	purinergic receptor P2X, ligand gated ion channel, 7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Autophagic Vacuole Membrane Lysosomal Membrane Integral Component Of Membrane Cytoplasmic Vesicle	Integral Component Of Nuclear Inner Membrane Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane Neuromuscular Junction Bleb Neuronal Cell Body Terminal Bouton Protein Complex Membrane Raft
	Molecular Function		Magnesium Ion Binding Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellular ATP-gated Cation Channel Activity Receptor Binding Copper Ion Binding Protein Binding ATP Binding Zinc Ion Binding Protein Homodimerization Activity Scaffold Protein Binding
	Biological Process	Autophagy	Activation Of MAPK Activity Cell Morphogenesis Phagolysosome Assembly Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Sodium Ion Transport Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Phospholipid Transfer To Membrane Cell Volume Homeostasis Membrane Budding Inflammatory Response Mitochondrion Organization Plasma Membrane Organization Cell Surface Receptor Signaling Pathway Response To Mechanical Stimulus Response To Zinc Ion Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Synaptic Vesicle Exocytosis Protein Processing Neuronal Action Potential Sensory Perception Of Pain Cytolysis Positive Regulation Of Bone Mineralization Cellular Response To Extracellular Stimulus Bleb Assembly Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Collagen Metabolic Process Response To ATP Response To Fluid Shear Stress Purinergic Nucleotide Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway T Cell Proliferation Response To Drug T Cell Homeostasis NAD Transport Negative Regulation Of MAPK Cascade Multicellular Organismal Protein Catabolic Process Innate Immune Response Phospholipid Translocation Negative Regulation Of Bone Resorption Positive Regulation Of Cytolysis Ceramide Biosynthetic Process Pore Complex Assembly Skeletal System Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Gram-positive Bacterium Release Of Sequestered Calcium Ion Into Cytosol Protein Oligomerization Positive Regulation Of Cytoskeleton Organization Response To Calcium Ion Response To Electrical Stimulus Regulation Of Killing Of Cells Of Other Organism Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Lymphocyte Apoptotic Process Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cation Transmembrane Transport
Pathways			The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Protein-Protein Interactions		3 interactors: P2RX7 RNASEH1 TCOF1	9 interactors: ACTB CASK EFNB3 EMP3 KRT31 KRTAP10-8 PANX1 SVIL TM9SF1
Entrez ID		10548	5027
HPRD ID		09987	03977
Ensembl ID		ENSG00000100926	ENSG00000089041
Uniprot IDs		O15321	Q99572
PDB IDs
Enriched GO Terms of Interacting Partners?		Phospholipid Transfer To Membrane NAD Transport Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Cytolysis Multicellular Organismal Protein Catabolic Process Positive Regulation Of Glutamate Secretion Multicellular Organismal Protein Metabolic Process Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Gamma-aminobutyric Acid Secretion Mitochondrion Organization Regulation Of Killing Of Cells Of Other Organism Bleb Assembly Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Amino Acid Transport Pore Complex Assembly Mitochondrial DNA Replication Negative Regulation Of Bone Resorption Regulation Of Glutamate Secretion Phagolysosome Assembly Skeletal System Development Negative Regulation Of Bone Remodeling Positive Regulation Of Prostaglandin Secretion Negative Regulation Of Tissue Remodeling Regulation Of Mitochondrial Depolarization Membrane Protein Ectodomain Proteolysis Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Icosanoid Secretion Positive Regulation Of Lymphocyte Apoptotic Process Mitochondrial DNA Metabolic Process Positive Regulation Of Interleukin-1 Secretion RRNA Transcription Regulation Of Interleukin-1 Beta Secretion Cytolysis Positive Regulation Of Fatty Acid Transport Response To ATP Positive Regulation Of Interleukin-1 Beta Production Neuronal Action Potential Mitochondrial Genome Maintenance Cell Volume Homeostasis Positive Regulation Of Interleukin-1 Production Transcription From RNA Polymerase I Promoter Positive Regulation Of Leukocyte Apoptotic Process Regulation Of Fatty Acid Transport Membrane Protein Proteolysis Regulation Of Bone Resorption Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Membrane Depolarization Release Of Sequestered Calcium Ion Into Cytosol Response To Fluid Shear Stress
Tagcloud ?		ancient bioinformatic cannibalism comprises confirms conservation continue dictyostelium discoideum drosophila embryogenesis extreme immunoreceptor maternally melanogaster members nonaspanins phagocytosis saccharomyces tm8 traf2 transmembrane zebrafish	adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Difference) ?		ancient bioinformatic cannibalism comprises confirms conservation continue dictyostelium discoideum drosophila embryogenesis extreme immunoreceptor maternally melanogaster members nonaspanins phagocytosis saccharomyces tm8 traf2 transmembrane zebrafish	adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Intersection) ?