CEBPE and KDM2B

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		CEBPE	KDM2B
Gene Name		CCAAT/enhancer binding protein (C/EBP), epsilon	lysine (K)-specific demethylase 2B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Nucleolus PcG Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Homodimerization Activity Protein Heterodimerization Activity	DNA Binding Protein Binding Zinc Ion Binding RRNA Binding Histone Demethylase Activity Histone Demethylase Activity (H3-K36 Specific)
	Biological Process	Transcription, DNA-templated Phagocytosis Defense Response Macrophage Differentiation Cytokine Biosynthetic Process Defense Response To Bacterium Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Spermatogenesis Histone Demethylation Midbrain-hindbrain Boundary Morphogenesis Fourth Ventricle Development Lateral Ventricle Development Third Ventricle Development Initiation Of Neural Tube Closure Forebrain Development Midbrain Development Hindbrain Development Histone H2A Monoubiquitination Negative Regulation Of Neuron Apoptotic Process Embryonic Camera-type Eye Morphogenesis Oxidation-reduction Process Histone H3-K36 Demethylation Negative Regulation Of Neural Precursor Cell Proliferation
Pathways			Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23512250 19684604)
Protein-Protein Interactions		44 interactors: ALX4 ATF3 ATF4 ATF5 BATF BATF2 BATF3 CCT7 CEBPA CEBPD CEBPG COPS3 CSNK1A1L DDIT3 DENND4A E2F1 EDA2R FOS FOSL1 GATA1 GPR22 GTF2A1L IL7 JUN KDM2B LDOC1 MED16 MLLT6 MYB NELFB PIAS1 POU2F1 PSAT1 RB1 SIPA1L1 SPI1 STAT6 TAF5L TBX2 TCEB2 UBE2I ZFP2 ZMYM2 ZNF384	4 interactors: CEBPE HIST1H3A LZTR1 UBE2D1
Entrez ID		1053	84678
HPRD ID		02852	12362
Ensembl ID		ENSG00000092067	ENSG00000089094
Uniprot IDs		Q15744	Q8NHM5
PDB IDs		3T92
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Leukocyte Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Cellular Process Myeloid Cell Differentiation Hemopoiesis Myeloid Leukocyte Differentiation Cellular Metabolic Process Immune System Development Negative Regulation Of Cellular Metabolic Process Organ Development Dendritic Cell Differentiation Anatomical Structure Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity System Development Myeloid Dendritic Cell Differentiation Leukocyte Activation Myeloid Dendritic Cell Activation	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA Replication-dependent Nucleosome Assembly Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA Methylation On Cytosine Chromatin Silencing At RDNA
Tagcloud ?		10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition ptprj relapsed runx1 sibs tp63 twinned	7b aberrant analog array axis azacitidine bypassed cd34 cyclopentanyl deazaadenosine di dysregulated dznep ezh2 g0 h3k27 h3k27me3 hypomethylating hypothesized landscape let marrows methylated nanostring p16 preliminary preventing repression tri
Tagcloud (Difference) ?		10months 12p absolutely aligned alive altogether apart arid5b associating bcp boy chance divergent etv6 girl gstm1 gstt1 haa ikzf1 leukocytosis microsatellite nqo1 predisposition ptprj relapsed runx1 sibs tp63 twinned	7b aberrant analog array axis azacitidine bypassed cd34 cyclopentanyl deazaadenosine di dysregulated dznep ezh2 g0 h3k27 h3k27me3 hypomethylating hypothesized landscape let marrows methylated nanostring p16 preliminary preventing repression tri
Tagcloud (Intersection) ?