CDX2 and PAX6

Number of citations of the paper that reports this interaction (PMID 10506141)
18

Data Source:
HPRD (in vivo, in vitro)

		CDX2	PAX6
Gene Name		caudal type homeobox 2	paired box 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleoplasm Transcriptional Repressor Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding AT DNA Binding Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Acetyltransferase Binding Co-SMAD Binding R-SMAD Binding HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Trophectodermal Cell Differentiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Endosome To Lysosome Transport Organ Morphogenesis Anterior/posterior Pattern Specification Somatic Stem Cell Maintenance Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Labyrinthine Layer Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Establishment Of Mitotic Spindle Orientation Blood Vessel Development Eye Development Cell Fate Determination Neural Crest Cell Migration Neuron Migration Negative Regulation Of Protein Phosphorylation Positive Regulation Of Neuroblast Proliferation Lens Development In Camera-type Eye Type B Pancreatic Cell Differentiation Pancreatic A Cell Development Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Axon Guidance Central Nervous System Development Salivary Gland Morphogenesis Visual Perception Response To Wounding Regulation Of Asymmetric Cell Division Organ Morphogenesis Dorsal/ventral Axis Specification Positive Regulation Of Gene Expression Regulation Of Neuron Projection Development Protein Ubiquitination Cerebellum Development Rhombomere Morphogenesis Olfactory Bulb Development Oligodendrocyte Cell Fate Specification Cerebral Cortex Regionalization Forebrain Anterior/posterior Pattern Specification Forebrain Dorsal/ventral Pattern Formation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Spinal Cord Motor Neuron Fate Specification Regulation Of Transcription From RNA Polymerase II Promoter Involved In Ventral Spinal Cord Interneuron Specification Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Pituitary Gland Development Interkinetic Nuclear Migration Signal Transduction Involved In Regulation Of Gene Expression Keratinocyte Differentiation Positive Regulation Of Epithelial Cell Differentiation Lacrimal Gland Development Cellular Response To Insulin Stimulus Protein Localization To Organelle Cellular Response To Drug Eye Photoreceptor Cell Development Glucose Homeostasis Positive Regulation Of Cell Fate Specification Cellular Response To Fibroblast Growth Factor Stimulus Response To Ethanol Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Timing Of Cell Differentiation Embryonic Camera-type Eye Morphogenesis Neuron Fate Commitment Astrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Retina Development In Camera-type Eye Iris Morphogenesis Cornea Development In Camera-type Eye Positive Regulation Of Glucagon Secretion Cellular Response To Glucose Stimulus Cellular Response To Prostaglandin E Stimulus Insulin Metabolic Process Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Neuron Migration
Pathways		Peptide hormone metabolism Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation	Peptide hormone metabolism Regulation of beta-cell development Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Regulation of gene expression in beta cells Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS			Body mass index ( 22344219)
Protein-Protein Interactions		13 interactors: ACAT2 CDK2 CREBBP EP300 GSK3B HNF1A MAPK1 MAPK14 PAX6 SMARCA4 SMARCB1 SMARCD1 UBB	30 interactors: CDX2 DIAPH1 DLG1 DYNLL1 EN1 EP300 HIPK2 HOMER3 HOXB1 INADL IPO13 LHX2 MAFG MITF NKIRAS2 PBX1 PKNOX1 PROX1 RAX RB1 RGS3 SHANK3 SIX3 SMARCA4 SOX10 SOX3 SUMO1 TBP TRIM11 VSX2
Entrez ID		1045	5080
HPRD ID		02622	06167
Ensembl ID			ENSG00000007372
Uniprot IDs		Q99626	F1T0F8 P26367 Q66SS1
PDB IDs			2CUE 6PAX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Heat Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Positive Regulation By Host Of Viral Transcription Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Organization Cellular Response To Heat Nucleosome Disassembly Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Developmental Process Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Organ Morphogenesis Response To Heat Chromosome Organization Transcription, DNA-templated Regulation Of Wnt Signaling Pathway Cell Cycle Process RNA Biosynthetic Process Anatomical Structure Morphogenesis Interaction With Symbiont Nucleobase-containing Compound Metabolic Process N-terminal Peptidyl-lysine Acetylation Embryo Development Response To Stress Multicellular Organismal Development Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Viral Transcription Cellular Nitrogen Compound Metabolic Process Innate Immune Response	Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Nervous System Development Anatomical Structure Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Organ Development Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Camera-type Eye Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development RNA Metabolic Process System Development Eye Development Multicellular Organismal Development Regulation Of Transcription, DNA-templated Sensory Organ Development Regulation Of Nucleic Acid-templated Transcription Developmental Process Organ Morphogenesis Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Neurogenesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chordate Embryonic Development Cellular Nitrogen Compound Metabolic Process Generation Of Neurons Embryo Development Ending In Birth Or Egg Hatching Embryonic Morphogenesis Pattern Specification Process Tissue Development
Tagcloud ?		blastocyst blastocysts buffalo caspase3 caspase6 caspase7 cleave cleaving cloning competence developmental dnmt1 dnmt3a ec embryos epigenetics h3k27me3 h3k9ac handmade hdac1 hmc ivf lc nanog oct4 pluripotency produced sox2 trophectoderm	11p13 armes compaction conservation controversy cosmids editing evolution fried fugu genitourinary genomics gilley idea implying intergenic isoforms london mammals noncoding pufferfish quite raises rcn1 rubripes synteny usage usual wt1
Tagcloud (Difference) ?		blastocyst blastocysts buffalo caspase3 caspase6 caspase7 cleave cleaving cloning competence developmental dnmt1 dnmt3a ec embryos epigenetics h3k27me3 h3k9ac handmade hdac1 hmc ivf lc nanog oct4 pluripotency produced sox2 trophectoderm	11p13 armes compaction conservation controversy cosmids editing evolution fried fugu genitourinary genomics gilley idea implying intergenic isoforms london mammals noncoding pufferfish quite raises rcn1 rubripes synteny usage usual wt1
Tagcloud (Intersection) ?