LILRB2 and FCGR1A

Number of citations of the paper that reports this interaction (PMID 9842885)
23

Data Source:
HPRD (in vitro)

		LILRB2	FCGR1A
Gene Name		leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	Fc fragment of IgG, high affinity Ia, receptor (CD64)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane	Plasma Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Receptor Activity Protein Binding Protein Phosphatase 1 Binding MHC Class Ib Protein Binding Inhibitory MHC Class I Receptor Activity MHC Class I Protein Binding Cell Adhesion Molecule Binding	Receptor Signaling Protein Activity Protein Binding IgG Binding
	Biological Process	Negative Regulation Of Antigen Processing And Presentation Positive Regulation Of T Cell Tolerance Induction Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Immune Response Negative Regulation Of Calcium Ion Transport Cellular Response To Lipopolysaccharide Regulation Of Dendritic Cell Differentiation	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Phagocytosis, Engulfment Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Interferon-gamma-mediated Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Interferon gamma signaling Interferon Signaling Cross-presentation of soluble exogenous antigens (endosomes) Role of phospholipids in phagocytosis Cytokine Signaling in Immune system Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Regulation of actin dynamics for phagocytic cup formation Adaptive Immune System Innate Immune System
Drugs			Cetuximab Etanercept Intravenous Immunoglobulin Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer Methyl aminolevulinate
Diseases
GWAS		HDL cholesterol ( 20686565)
Protein-Protein Interactions		7 interactors: FCGR1A HLA-A HLA-B HLA-C HLA-F HLA-G PTPN6	10 interactors: APCS CRKL CRP FCAR FCGR3A HCK HRG LAT LILRB2 SYK
Entrez ID		10288	2209
HPRD ID		11994	00904
Ensembl ID		ENSG00000131042	ENSG00000150337
Uniprot IDs		A2IXV5 A8MU67 C9JF29 Q8N423	P12314
PDB IDs		2DYP 2GW5 4LLA	3RJD
Enriched GO Terms of Interacting Partners?		Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Response To Interferon-gamma Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of T Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Positive Regulation Of Leukocyte Mediated Cytotoxicity Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Cellular Response To Cytokine Stimulus Antigen Processing And Presentation Positive Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Response To Cytokine Positive Regulation Of Adaptive Immune Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response Regulation Of Immune System Process Defense Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Cellular Response To Organic Substance Immune System Process Response To Organic Substance Protection From Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Surface Receptor Signaling Pathway Response To Stress Negative Regulation Of Immune System Process Regulation Of Dendritic Cell Differentiation Negative Regulation Of Immune Response Detection Of Bacterium Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Signal Transduction Detection Of Biotic Stimulus	Immune Response Regulation Of Immune System Process Defense Response Immune System Process Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Stress Inflammatory Response Immune Response-regulating Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Other Organism Response To Biotic Stimulus Exocytosis Vesicle-mediated Transport Innate Immune Response Regulation Of Superoxide Anion Generation Integrin-mediated Signaling Pathway Regulation Of Wound Healing Response To Stimulus Regulation Of Cell Activation Response To Bacterium Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Secretion By Cell Defense Response To Bacterium Platelet Activation Positive Regulation Of Tissue Remodeling Regulation Of Platelet Activation Wound Healing Regulation Of Cell Adhesion Secretion Endocytosis Peptidyl-tyrosine Autophosphorylation Acute-phase Response Regulation Of Cell Adhesion Mediated By Integrin Response To Fungus Response To Wounding Leukocyte Degranulation Response To Organic Substance Regulation Of T Cell Activation Regulated Secretory Pathway Regulation Of Phagocytosis Negative Regulation Of Wound Healing Defense Response To Gram-positive Bacterium Regulation Of Tissue Remodeling
Tagcloud ?		abilities acetylcholine adrenergic alpha7 alpha7nachr ars bindings characters deterioration drivers eph exact fcgamma fcgammariib immunoglobulin ltp neurotrophin nicotinic oligomeric ortholog p75ntr pirb presumed prion prpc rescuing spine summarizes synapse	ababa addis apart aucs bcl2 blr1 bpi ccl19 colour contacts dcrt discriminatory foxp3 fpr1 household il4d2 il7r latently ltbi ltf marco mlpa mmp9 multiplex qft smear tb tgfb1 uninfected
Tagcloud (Difference) ?		abilities acetylcholine adrenergic alpha7 alpha7nachr ars bindings characters deterioration drivers eph exact fcgamma fcgammariib immunoglobulin ltp neurotrophin nicotinic oligomeric ortholog p75ntr pirb presumed prion prpc rescuing spine summarizes synapse	ababa addis apart aucs bcl2 blr1 bpi ccl19 colour contacts dcrt discriminatory foxp3 fpr1 household il4d2 il7r latently ltbi ltf marco mlpa mmp9 multiplex qft smear tb tgfb1 uninfected
Tagcloud (Intersection) ?