CDK2AP2 and EED

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CDK2AP2	EED
Gene Name		cyclin-dependent kinase 2 associated protein 2	embryonic ectoderm development
Image
Gene Ontology Annotations	Cellular Component		Sex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm ESC/E(Z) Complex Pronucleus
	Molecular Function		Chromatin Binding Protein Binding Histone Methyltransferase Activity Identical Protein Binding
	Biological Process		Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Gene Expression Histone Methylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Histone H3-K27 Methylation
Pathways			Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: A2M APP CDK2AP1 DBN1 EED EEF1G HSF4 IKZF1 MBTPS1 MRFAP1L1 PYCR1 RCC1 RPLP1 TRA2A WARS YIF1A ZBTB48	38 interactors: AEBP2 ANXA5 BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 HDAC1 HDAC2 HDAC3 HIST1H1A HIST1H3A ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PINK1 PJA1 PPP1CA PPP1R8 RBBP4 RPS10 SELENBP1 SMYD3 TGS1 TSC22D1 UBE2W YY1 ZBED8 ZFP42
Entrez ID		10263	8726
HPRD ID		13242	09343
Ensembl ID		ENSG00000167797	ENSG00000074266
Uniprot IDs		O75956 Q6IAV4	E9PJK2 O75530
PDB IDs		2M1L	3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27
Enriched GO Terms of Interacting Partners?		Gene Expression Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Nuclease Activity Positive Regulation Of Neutrophil Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Platelet Degranulation Cellular Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Macromolecule Biosynthetic Process Tryptophanyl-tRNA Aminoacylation Synaptic Growth At Neuromuscular Junction Negative Regulation Of Complement Activation, Lectin Pathway Cellular Aromatic Compound Metabolic Process Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Metabolic Process Regulation Of Protein Metabolic Process Collateral Sprouting In Absence Of Injury Cell Communication By Chemical Coupling Regulation Of Multicellular Organism Growth Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Positive Regulation Of Protein Modification Process Cholesterol Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition L-proline Biosynthetic Process Sterol Metabolic Process Response To Unfolded Protein Cellular Protein Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Hydrolase Activity Protein Metabolic Process Axon Choice Point Recognition Positive Regulation Of NK T Cell Differentiation Regulation Of Protein Phosphorylation MRNA Metabolic Process Histone H3-K9 Demethylation Response To Endoplasmic Reticulum Stress Positive Regulation Of Ran GTPase Activity Positive Regulation Of Granulocyte Differentiation	Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Organization Chromosome Organization Chromatin Modification Negative Regulation Of Gene Expression DNA Methylation DNA Methylation On Cytosine Organelle Organization Negative Regulation Of Transcription, DNA-templated DNA Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter C-5 Methylation Of Cytosine Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Histone H3-K9 Methylation Histone H3-K27 Methylation DNA Metabolic Process Chromatin Silencing Histone H3-K9 Modification Transcription, DNA-templated Gene Silencing Positive Regulation Of Histone H3-K4 Methylation Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Negative Regulation Of Histone Methylation Cell-matrix Adhesion Involved In Ameboidal Cell Migration Histone H4 Deacetylation Cellular Metabolic Process Regulation Of Histone H3-K4 Methylation Cellular Macromolecule Biosynthetic Process Circadian Regulation Of Gene Expression RNA Metabolic Process Macromolecule Biosynthetic Process
Tagcloud ?			70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Difference) ?			70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Intersection) ?