GPHN and ACADVL

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GPHN	ACADVL
Gene Name		gephyrin	acyl-CoA dehydrogenase, very long chain
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Cell Junction Postsynaptic Membrane Inhibitory Synapse	Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Nucleoid
	Molecular Function	ATP Binding Transferase Activity Metal Ion Binding Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity	Acyl-CoA Dehydrogenase Activity Long-chain-acyl-CoA Dehydrogenase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Establishment Of Synaptic Specificity At Neuromuscular Junction Molybdenum Incorporation Into Molybdenum-molybdopterin Complex Molybdopterin Cofactor Biosynthetic Process Small Molecule Metabolic Process Glycine Receptor Clustering	Temperature Homeostasis Fatty Acid Beta-oxidation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Energy Derivation By Oxidation Of Organic Compounds Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Cellular Lipid Metabolic Process Cellular Protein Metabolic Process Small Molecule Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Fatty Acid Oxidation Regulation Of Cholesterol Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Molybdenum cofactor biosynthesis Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism	Fatty acid, triacylglycerol, and ketone body metabolism IRE1alpha activates chaperones Metabolism of lipids and lipoproteins Mitochondrial Fatty Acid Beta-Oxidation mitochondrial fatty acid beta-oxidation of saturated fatty acids XBP1(S) activates chaperone genes Beta oxidation of palmitoyl-CoA to myristoyl-CoA Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Depression (quantitative trait) ( 23290196)
Protein-Protein Interactions		13 interactors: ACADVL ARHGEF9 DYNLL1 DYNLL2 ENAH GABARAP GLRB KHDRBS1 MTOR PFN1 PIN1 SPATS1 TUBA4A	3 interactors: GPHN RPSA SOCS3
Entrez ID		10243	37
HPRD ID		04893	01940
Ensembl ID		ENSG00000171723	ENSG00000072778
Uniprot IDs		F5H039 F8W7D6 Q9NQX3	B3KPA6 P49748
PDB IDs		1JLJ	2UXW 3B96
Enriched GO Terms of Interacting Partners?		Cellular Response To Stimulus Response To Stimulus Signal Transduction Apoptotic Signaling Pathway Signaling G2/M Transition Of Mitotic Cell Cycle Cell Communication Positive Regulation Of Organelle Organization Regulation Of Intracellular Transport Regulation Of Organelle Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Fatty Acid Oxidation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cytoskeleton Organization Cellular Response To Organic Substance Positive Regulation Of Intracellular Transport Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Surface Receptor Signaling Pathway Regulation Of Rho GTPase Activity Positive Regulation Of Mitochondrion Organization Microtubule-based Process Regulation Of Stress Fiber Assembly Regulation Of Carbohydrate Utilization Synaptic Target Recognition Regulation Of Catalytic Activity Regulation Of Rho Protein Signal Transduction Exocytosis Platelet Degranulation Positive Regulation Of Translation Response To Organic Substance Transport Regulation Of Fatty Acid Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Mitochondrion Organization Positive Regulation Of RNA Export From Nucleus Apoptotic Process Programmed Cell Death Regulation Of Signal Transduction Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Neural Tube Closure Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Positive Regulation Of Actin Filament Polymerization Cell Death Death	Glycine Receptor Clustering Molybdenum Incorporation Into Molybdenum-molybdopterin Complex RRNA Export From Nucleus Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Establishment Of Synaptic Specificity At Neuromuscular Junction Spongiotrophoblast Differentiation Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Transport RRNA 3'-end Processing Protein Localization To Membrane Molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Ribosomal Small Subunit Assembly Branching Involved In Labyrinthine Layer Morphogenesis Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA Spongiotrophoblast Layer Development Trophoblast Giant Cell Differentiation Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of JAK-STAT Cascade Labyrinthine Layer Morphogenesis Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Postsynaptic Membrane Organization Embryonic Placenta Morphogenesis Ribosome Assembly Maturation Of SSU-rRNA Membrane Organization Cell Differentiation Involved In Embryonic Placenta Development Placenta Blood Vessel Development Negative Regulation Of Insulin Receptor Signaling Pathway Ribosomal Small Subunit Biogenesis Response To Growth Hormone Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Protein Metabolic Process Receptor Clustering Neuromuscular Junction Development JAK-STAT Cascade Labyrinthine Layer Development Regulation Of Insulin Receptor Signaling Pathway RNA Phosphodiester Bond Hydrolysis, Endonucleolytic RNA Export From Nucleus Cellular Protein Localization Synapse Assembly Regulation Of Cellular Response To Insulin Stimulus Water-soluble Vitamin Metabolic Process
Tagcloud ?		albeit bcl2 characterizing copy cytogenetic ep300 fl gains hit hodgkin igh illustrate incompletely infrequently insufficient karyotype losses lymphoblastic lymphoma neil1 principally q21 q32 rearrangement specimen transform translocations warrant workup	2t 390del 7123997t acyl boy coa decompensation deterioration diagnose downhill glu130del hong illustrates inborn kong lives newborn obviated opportunity prompt save siblings succumbed sudden tandem treatable unexpected urge vlcad
Tagcloud (Difference) ?		albeit bcl2 characterizing copy cytogenetic ep300 fl gains hit hodgkin igh illustrate incompletely infrequently insufficient karyotype losses lymphoblastic lymphoma neil1 principally q21 q32 rearrangement specimen transform translocations warrant workup	2t 390del 7123997t acyl boy coa decompensation deterioration diagnose downhill glu130del hong illustrates inborn kong lives newborn obviated opportunity prompt save siblings succumbed sudden tandem treatable unexpected urge vlcad
Tagcloud (Intersection) ?