TOPORS and HABP4

Number of citations of the paper that reports this interaction (PMID 16455055)
3

Data Source:
HPRD (two hybrid)

		TOPORS	HABP4
Gene Name		topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	hyaluronan binding protein 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Spindle Pole Gamma-tubulin Complex Nucleus Centriole Cytoplasmic Dynein Complex PML Body Nuclear Speck Midbody Photoreceptor Connecting Cilium Ciliary Basal Body	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Sarcomere
	Molecular Function	DNA Binding Antigen Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity DNA Topoisomerase Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Retina Layer Formation Protein Sumoylation Protein Localization To Nucleus Photoreceptor Cell Outer Segment Organization Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Retinal Rod Cell Development Retinal Cone Cell Development Positive Regulation Of Ubiquitin-protein Transferase Activity Maintenance Of Protein Location In Nucleus Protein K48-linked Ubiquitination	Platelet Degranulation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Blood Coagulation Platelet Activation Negative Regulation Of DNA Binding Cellular Response To Mechanical Stimulus
Pathways			Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Immune response to smallpox vaccine (IL-6) ( 22610502)
Protein-Protein Interactions		24 interactors: CASP8 H2AFX HABP4 MTDH NKX3-1 SATB1 SERBP1 SIN3A SNIP1 SUMO1 SUMO2 TOP1 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2J1 UBE2L6 UBE2N UBE2W	24 interactors: C1QBP CHD3 DAXX ENO2 FRA10AC1 GNB2L1 HMGXB4 KAT5 PIAS3 PPP1R15A PRKCA PRKCB PRKCD PRKCG PRKCQ PRKCZ PRMT1 SRSF9 SYNCRIP TOPORS TP53 UBE2I VIM YBX1
Entrez ID		10210	22927
HPRD ID		11642	13628
Ensembl ID		ENSG00000197579	ENSG00000130956
Uniprot IDs		Q9NS56	Q5JVS0
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Polyubiquitination Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Innate Immune Response Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Cellular Macromolecule Catabolic Process Cellular Response To Organic Substance Protein K48-linked Ubiquitination Positive Regulation Of Innate Immune Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Ubiquitin-dependent Protein Catabolic Process Toll-like Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Response To Oxygen Levels Regulation Of DNA-templated Transcription In Response To Stress Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Proteolysis Response To Organic Substance Negative Regulation Of Gene Expression Cellular Protein Modification Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Stress Proteolysis Regulation Of Metabolic Process Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Hypoxia Positive Regulation Of Cellular Protein Catabolic Process Catabolic Process DNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process	Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Apoptotic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Cell Death Death Regulation Of Protein Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Blood Coagulation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Hemostasis Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Platelet Activation Viral Process Regulation Of Body Fluid Levels Negative Regulation Of Signaling Wound Healing Peptidyl-amino Acid Modification Regulation Of RNA Metabolic Process Response To Wounding Chromatin Organization Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of Platelet Aggregation Positive Regulation Of Phospholipase Activity Regulation Of Cell Death Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Phospholipase Activity Histone H3-T6 Phosphorylation Positive Regulation Of Lipase Activity Chromatin Modification Enzyme Linked Receptor Protein Signaling Pathway Organelle Organization Positive Regulation Of Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cell Death Protein Sumoylation
Tagcloud ?		bindingprotein blockade condition deprivation diphosphate e3 eliminates ern1 finction finger glioma glutamine matrin nm23 nme nme6 nucleoside ofrybpi oftumor regulatedpa26 rybp sesn1 tp53 tp53bp1 tp53bpi tp53tg1 u87 zmat3	9q altered cgi contexts experimentally explain familiar functionally give haplotype hek293t identity inducer insights ki knockdown link microchip overexpression paralogs prompting qrt serbp1 shared similarity sirna thapsigargin transcriptome tumorigenic
Tagcloud (Difference) ?		bindingprotein blockade condition deprivation diphosphate e3 eliminates ern1 finction finger glioma glutamine matrin nm23 nme nme6 nucleoside ofrybpi oftumor regulatedpa26 rybp sesn1 tp53 tp53bp1 tp53bpi tp53tg1 u87 zmat3	9q altered cgi contexts experimentally explain familiar functionally give haplotype hek293t identity inducer insights ki knockdown link microchip overexpression paralogs prompting qrt serbp1 shared similarity sirna thapsigargin transcriptome tumorigenic
Tagcloud (Intersection) ?