ADAM10 and EFNA2

Number of citations of the paper that reports this interaction (PMID 10958785)
89

Data Source:
HPRD (in vitro, in vivo)

		ADAM10	EFNA2
Gene Name		ADAM metallopeptidase domain 10	ephrin-A2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Golgi-associated Vesicle Plasma Membrane Focal Adhesion Cell Surface Postsynaptic Density Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Perinuclear Endoplasmic Reticulum Tetraspanin-enriched Microdomain	Extracellular Region Plasma Membrane Anchored Component Of Membrane Neuromuscular Junction Perikaryon
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Receptor Binding Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding Protein Kinase Binding Protein Homodimerization Activity	Ephrin Receptor Binding
	Biological Process	In Utero Embryonic Development Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Integrin-mediated Signaling Pathway Cell-cell Signaling Axon Guidance Positive Regulation Of Cell Proliferation Positive Regulation Of T Cell Chemotaxis Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Tumor Necrosis Factor Monocyte Activation Ephrin Receptor Signaling Pathway PMA-inducible Membrane Protein Ectodomain Proteolysis Constitutive Protein Ectodomain Proteolysis	Cell-cell Signaling Axon Guidance Olfactory Bulb Development Osteoclast Differentiation Bone Remodeling Ephrin Receptor Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Degradation of the extracellular matrix Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Collagen degradation Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Signaling by EGFR Signaling by EGFR in Cancer Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: AXL DLL1 EFNA1 EFNA2 EPHA3 SH3D19 TGFA	6 interactors: ADAM10 EPHA2 EPHA3 EPHA5 RUNX1 ZHX1
Entrez ID		102	1943
HPRD ID		03723	04132
Ensembl ID		ENSG00000137845	ENSG00000099617
Uniprot IDs		B4DU28 O14672	O43921
PDB IDs		1M1I	2WO3
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Ephrin Receptor Signaling Pathway Anatomical Structure Morphogenesis Generation Of Neurons Cell Morphogenesis Involved In Differentiation Neurogenesis Cell Surface Receptor Signaling Pathway Cell Development Substrate Adhesion-dependent Cell Spreading Regulation Of Epithelial To Mesenchymal Transition Cell Morphogenesis Axon Guidance Nervous System Development System Development Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Axonogenesis Regulation Of Signal Transduction Multicellular Organismal Development Regulation Of Neuron Differentiation Axon Development Anatomical Structure Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Tissue Remodeling Chemotaxis Organ Development Regulation Of Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Auditory Receptor Cell Differentiation Hemopoiesis Regulation Of Signaling Neuron Projection Morphogenesis Signal Transduction Activation Of MAPK Activity Immune System Development Regulation Of Neurogenesis Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Intracellular Signal Transduction Developmental Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Differentiation Response To External Stimulus Signaling Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell Communication	Ephrin Receptor Signaling Pathway Neuron Development Axon Guidance Neuron Differentiation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Generation Of Neurons Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Neurogenesis Cell Morphogenesis Involved In Differentiation Cell Development Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Rho GTPase Activity Peptidyl-tyrosine Phosphorylation Nervous System Development Regulation Of Rho Protein Signal Transduction Cell Morphogenesis Anatomical Structure Morphogenesis Cell Projection Organization Locomotion Protein Phosphorylation Developmental Process Movement Of Cell Or Subcellular Component Regulation Of Ras GTPase Activity Notochord Cell Development Constitutive Protein Ectodomain Proteolysis Regulation Of Cell Adhesion Regulation Of Ras Protein Signal Transduction Response To External Stimulus Positive Regulation Of Progesterone Secretion Phosphorylation Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Organization Regulation Of GTPase Activity Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching PMA-inducible Membrane Protein Ectodomain Proteolysis Axial Mesoderm Formation Regulation Of Progesterone Secretion System Development Regulation Of Hair Follicle Cell Proliferation Peptidyl-amino Acid Modification Notochord Formation
Tagcloud ?		actually ameliorating amyloidogenic appswe bace1 behavioral concept copyright deficits dramatic highlights hyperphosphorylation interpretation jnk modifying neuropathology plaque potently powerfully preclinical protected ps1 ps1de9 reserved rights secretase slow sp600125 vehicle	16p13 16q12 19p13 21q21 affymetrix agar arrays cd133 cd133high cd133low colonies die extracranial gains genotyping heterozygosity il2rgammac initiating injections lethal nb neurosphere neurospheres orthotopic persist relapses soft tics uncontrolled
Tagcloud (Difference) ?		actually ameliorating amyloidogenic appswe bace1 behavioral concept copyright deficits dramatic highlights hyperphosphorylation interpretation jnk modifying neuropathology plaque potently powerfully preclinical protected ps1 ps1de9 reserved rights secretase slow sp600125 vehicle	16p13 16q12 19p13 21q21 affymetrix agar arrays cd133 cd133high cd133low colonies die extracranial gains genotyping heterozygosity il2rgammac initiating injections lethal nb neurosphere neurospheres orthotopic persist relapses soft tics uncontrolled
Tagcloud (Intersection) ?