PSME3 and CASP7

Number of citations of the paper that reports this interaction (PMID 11859414)
3

Data Source:
HPRD (in vitro)

		PSME3	CASP7
Gene Name		proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)	caspase 7, apoptosis-related cysteine peptidase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Activator Complex Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	P53 Binding Protein Binding Endopeptidase Activator Activity MDM2/MDM4 Family Protein Binding	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Positive Regulation Of Endopeptidase Activity Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis
Pathways		Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway	Activation of caspases through apoptosome-mediated cleavage Apoptotic cleavage of cellular proteins Apoptotic factor-mediated response SMAC binds to IAPs Apoptotic execution phase Programmed Cell Death SMAC-mediated dissociation of IAP:caspase complexes Cytochrome c-mediated apoptotic response SMAC-mediated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins Intrinsic Pathway for Apoptosis
Drugs			Fica
Diseases
GWAS			Vitiligo ( 22561518)
Protein-Protein Interactions		35 interactors: ADAP1 AICDA ATN1 ATP5B BBS2 CASP3 CASP6 CASP7 COIL CREBBP DIP2A DTNBP1 EAF1 FBXO7 FXR2 HSPA5 ITPKB KANSL1 MDM2 NCOA3 NUDT18 PFDN5 PRKAB2 PRR13 SERF2 SIRT1 SMURF1 SPG7 TBXA2R TNFAIP8L1 TP53 TXN2 WDR25 YWHAQ ZCCHC10	60 interactors: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HSPA5 KRT18 LYN MAPT MAX MEF2A MEF2D NEDD4 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A UBE4B VIM XIAP
Entrez ID		10197	840
HPRD ID		05500	03457
Ensembl ID		ENSG00000131467	ENSG00000165806
Uniprot IDs		P61289 Q6MZZ1	B4DWA2 P55210
PDB IDs			1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1MIA 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2
Enriched GO Terms of Interacting Partners?		Response To Nutrient Levels Response To Extracellular Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Cellular Response To Nutrient Levels Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Helicase Activity Cellular Response To Extracellular Stimulus Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitochondrion Organization Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Oxygen Levels Peptidyl-lysine Acetylation Peptidyl-lysine Modification Positive Regulation Of Cell Aging Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction Apoptotic Process Protein Acetylation Glial Cell Apoptotic Process Programmed Cell Death Regulation Of Gene Expression Anatomical Structure Development Response To Hypoxia Developmental Process Cell Death Death Mitochondrial Transport Response To Organic Substance Regulation Of Cellular Process Neuron Apoptotic Process Response To Antibiotic Regulation Of Signaling Cellular Component Disassembly Involved In Execution Phase Of Apoptosis ER Overload Response Apoptotic Signaling Pathway Neuron Death Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Intracellular Transport Proteolysis Multicellular Organismal Development Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Execution Phase Of Apoptosis Cellular Response To Oxidative Stress	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Process Execution Phase Of Apoptosis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Stress Response To Stimulus Regulation Of Cellular Component Organization Cell Communication Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Intracellular Signal Transduction Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Process Regulation Of Signaling Myeloid Cell Differentiation System Development Regulation Of Metabolic Process Cellular Response To Organic Substance Viral Process Regulation Of Proteolysis Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Peptidase Activity Anatomical Structure Development Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Multicellular Organismal Development Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		11sgamma amplification balance basal bioinformatics biotinylated called cdna ends export feedback immunoprecipitation ligase loop luciferase maintains negatively p53 pa28gamma precipitation promoter promotes promoting race reggamma regulates rlm start utilizing	balb casp3 casp8 caspase3 closure d10 d5 d7 dermal execution extrinsic fasr harvested healing innovation intersect intrinsic mechanistically mucosal preprogrammed punch scarring therapeutics tnfrsf1b tongue tradd trp53 wound wounds
Tagcloud (Difference) ?		11sgamma amplification balance basal bioinformatics biotinylated called cdna ends export feedback immunoprecipitation ligase loop luciferase maintains negatively p53 pa28gamma precipitation promoter promotes promoting race reggamma regulates rlm start utilizing	balb casp3 casp8 caspase3 closure d10 d5 d7 dermal execution extrinsic fasr harvested healing innovation intersect intrinsic mechanistically mucosal preprogrammed punch scarring therapeutics tnfrsf1b tongue tradd trp53 wound wounds
Tagcloud (Intersection) ?