ARPC3 and RPS4X

Number of citations of the paper that reports this interaction (PMID 9889097)
190

Data Source:
BioGRID (two hybrid)

		ARPC3	RPS4X
Gene Name		actin related protein 2/3 complex, subunit 3, 21kDa	ribosomal protein S4, X-linked
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Extracellular Vesicular Exosome	Cytosol Ribosome Polysome Focal Adhesion Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Structural Constituent Of Ribosome RRNA Binding Poly(A) RNA Binding
	Biological Process	Movement Of Cell Or Subcellular Component Axon Guidance Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Ephrin Receptor Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Multicellular Organismal Development Positive Regulation Of Cell Proliferation Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process Positive Regulation Of Translation
Pathways		EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ACTR3 ARAP1 ARPC4 BAG6 CDKN2B CETP EFTUD2 GOLGA2 HOXA3 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 PRMT1 RPS4X THNSL2 WAS WASF2 WASL	11 interactors: ARPC3 CAMK2D CTBP2 HNRNPH3 MCM2 RPS15 RPS5 RPS6 RPS7 RPS8 RPS9
Entrez ID		10094	6191
HPRD ID		09175	02427
Ensembl ID		ENSG00000111229
Uniprot IDs		O15145	B2R491 P62701
PDB IDs			3J3A
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Phagocytosis Regulation Of Cytoskeleton Organization Fc Receptor Signaling Pathway Regulation Of Cell Projection Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Filopodium Assembly Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Actin Cytoskeleton Organization Regulation Of Filopodium Assembly Actin Filament-based Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Actin Filament-based Movement Positive Regulation Of Cytoskeleton Organization Immune System Process Immune Response-regulating Signaling Pathway Innate Immune Response Negative Regulation Of Stress Fiber Assembly Actin Polymerization Or Depolymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Lamellipodium Assembly Defense Response Cell Cycle Regulation Of Organelle Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Immune Response Megakaryocyte Differentiation Regulation Of Actin Nucleation Regulation Of Lamellipodium Assembly Cytoskeleton Organization Positive Regulation Of Organelle Organization Immune Response Arp2/3 Complex-mediated Actin Nucleation Regulation Of Immune System Process Regulation Of Immune Response Actin Filament Polymerization Regulation Of Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process	Viral Life Cycle Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Protein Localization To Endoplasmic Reticulum Translational Termination Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Protein Targeting To Membrane Translational Elongation RNA Catabolic Process Cellular Protein Complex Disassembly Protein Complex Disassembly Establishment Of Protein Localization To Membrane Translational Initiation MRNA Metabolic Process Viral Process Ribosomal Small Subunit Biogenesis Establishment Of Protein Localization To Organelle Protein Localization To Membrane Protein Targeting Aromatic Compound Catabolic Process Protein Localization To Organelle Translation Cytoplasmic Transport RRNA Processing RRNA Metabolic Process Cellular Macromolecule Catabolic Process Membrane Organization Ribosome Biogenesis Intracellular Protein Transport Ribonucleoprotein Complex Biogenesis Ribosomal Small Subunit Assembly Cellular Protein Localization RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Protein Transport Establishment Of Protein Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression RNA Biosynthetic Process Intracellular Transport Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Translational Fidelity Macromolecule Biosynthetic Process
Tagcloud ?		aberrant coincident collective combinatorial computational concurrently consider cytoskeleton dysregulated enriched extensive focal metastasis metastatic microrna micrornas mounting nodes notable numerous organization perturbed rankl repression reveals summary tgfb1 transcripts upstream	aberrant blastocyst bovine cattle clones cows embryo embryos freemartin gestation hatched hprt inner lost mecp2 pregnancies recipient reconstructed rq scnt slc25a6 somatic telomerase transcript transfer twin xiap xist zfx
Tagcloud (Difference) ?		coincident collective combinatorial computational concurrently consider cytoskeleton dysregulated enriched extensive focal metastasis metastatic microrna micrornas mounting nodes notable numerous organization perturbed rankl repression reveals summary tgfb1 transcripts upstream	blastocyst bovine cattle clones cows embryo embryos freemartin gestation hatched hprt inner lost mecp2 pregnancies recipient reconstructed rq scnt slc25a6 somatic telomerase transcript transfer twin xiap xist zfx
Tagcloud (Intersection) ?		aberrant