ABCC5 and SMC2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ABCC5	SMC2
Gene Name		ATP-binding cassette, sub-family C (CFTR/MRP), member 5	structural maintenance of chromosomes 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Nuclear Chromosome Condensed Chromosome Condensin Complex Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	ATP Binding Organic Anion Transmembrane Transporter Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances	Protein Binding ATP Binding Protein Heterodimerization Activity
	Biological Process	Carbohydrate Metabolic Process Transport Pathogenesis Organic Anion Transport Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Biosynthetic Process Small Molecule Metabolic Process Transmembrane Transport	Mitotic Cell Cycle Mitotic Chromosome Condensation Meiotic Chromosome Condensation Meiotic Chromosome Segregation Cell Division Kinetochore Organization
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation ABC-family proteins mediated transport Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective SLC26A2 causes chondrodysplasias Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D Hyaluronan metabolism MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates Hyaluronan biosynthesis and export MPS VI - Maroteaux-Lamy syndrome	Mitotic Prometaphase Mitotic Prophase Condensation of Prophase Chromosomes Cell Cycle, Mitotic M Phase Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS			Orofacial clefts (interaction) ( 21618603)
Protein-Protein Interactions		4 interactors: AK2 RBP5 SERPINA3 SMC2	8 interactors: ABCC5 DISC1 DNMT3B GULP1 LIG4 NCAPD2 SMC4 TRAF3IP1
Entrez ID		10057	10592
HPRD ID		06898	09277
Ensembl ID		ENSG00000114770	ENSG00000136824
Uniprot IDs		O15440	A8K984 B3KMB1 B7ZLZ7 O95347 Q05BV1 Q05D74 Q6IPS5 Q7Z2X1
PDB IDs
Enriched GO Terms of Interacting Partners?		ADP Biosynthetic Process DATP Metabolic Process Meiotic Chromosome Condensation Nucleoside Diphosphate Biosynthetic Process ADP Metabolic Process AMP Metabolic Process Response To Thyroid Hormone Maintenance Of Gastrointestinal Epithelium Nucleobase-containing Small Molecule Interconversion Epithelial Structure Maintenance Deoxyribonucleoside Triphosphate Metabolic Process Mitotic Chromosome Condensation Kinetochore Organization Acute-phase Response	Mitotic Chromosome Condensation Chromosome Condensation Organelle Organization Chromosome Organization DNA Metabolic Process Positive Regulation Of Neurogenesis Mitotic Sister Chromatid Segregation Cell Division DNA Ligation Involved In DNA Recombination Sister Chromatid Segregation Positive Regulation Of Cell Development S-adenosylmethioninamine Metabolic Process Response To Ionizing Radiation Regulation Of Neurogenesis Meiotic Chromosome Condensation DNA Methylation On Cytosine Within A CG Sequence DNA Packaging C-5 Methylation Of Cytosine Lagging Strand Elongation Pro-B Cell Differentiation S-adenosylhomocysteine Metabolic Process Regulation Of Cell Development Positive Regulation Of Cell Differentiation Chromosome Segregation Methylation-dependent Chromatin Silencing Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Establishment Of Integrated Proviral Latency Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination Hyaluronan Biosynthetic Process DNA Ligation Involved In DNA Repair DNA Conformation Change Lymphoid Progenitor Cell Differentiation Negative Regulation Of Histone H3-K9 Methylation DNA Methylation On Cytosine Nervous System Development Phagocytosis, Engulfment Mitotic Nuclear Division Negative Regulation Of Interferon-beta Production DNA Ligation Positive Regulation Of Histone H3-K4 Methylation Nucleotide-excision Repair, DNA Gap Filling Mitochondrial Calcium Ion Homeostasis Cellular Response To Lithium Ion Membrane Invagination Protein Complex Localization Negative Regulation Of Histone Methylation Regulation Of Synapse Maturation Post-anal Tail Morphogenesis
Tagcloud ?		24c 24t 388g 521c abcc2 bjc bjcancer ces1 clarifying com diarrhoea doi glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn ugt1a1 www	called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 nek2 p45 proteasome proteolysis pull repeats seventh smc1 telophase
Tagcloud (Difference) ?		24c 24t 388g 521c abcc2 bjc bjcancer ces1 clarifying com diarrhoea doi glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn ugt1a1 www	called complementary cyclins dissociated dnas ectopic elucidate eventually g2 gst hec heptad hydrolyzes inhibits interacts leucine mitosis mitotic modulate mss1 nek2 p45 proteasome proteolysis pull repeats seventh smc1 telophase
Tagcloud (Intersection) ?