TANK and APBA3

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		TANK	APBA3
Gene Name		TRAF family member-associated NFKB activator	amyloid beta (A4) precursor protein-binding, family A, member 3
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding	Beta-amyloid Binding Enzyme Inhibitor Activity Protein Binding Enzyme Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Innate Immune Response	In Utero Embryonic Development Synaptic Transmission Regulation Of Gene Expression Protein Transport Negative Regulation Of Catalytic Activity
Pathways		Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated IRF7 activation MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS		Dietary macronutrient intake ( 23372041) Educational attainment ( 23722424) Obesity-related traits ( 23251661) Presence of antiphospholipid antibodies ( 23509613) Subcutaneous adipose tissue ( 22589738) Treatment response for severe sepsis ( 22310353)
Protein-Protein Interactions		31 interactors: AIMP2 APBA3 APP ATP6V1H BIK CEP63 CHUK COPB1 FBLN1 HLA-C IKBKB IKBKE IKBKG INPP5K KPNA2 LAMC1 MAP4K5 MARCH5 PLK1 RACGAP1 SDC4 SMAD3 SRSF11 TBK1 TP53BP2 TRAF1 TRAF2 TRAF3 TRIM37 USP7 ZC3H12A	6 interactors: APP AZI2 BCR EGFR TANK TBKBP1
Entrez ID		10010	9546
HPRD ID		04870	05038
Ensembl ID		ENSG00000136560	ENSG00000011132
Uniprot IDs		B2R7S3 Q6NW12 Q92844	O96018
PDB IDs		1KZZ 1L0A	2YT7 2YT8
Enriched GO Terms of Interacting Partners?		TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytokine Production Apoptotic Process Viral Process Regulation Of Innate Immune Response Programmed Cell Death Cell Death Death Cellular Response To Tumor Necrosis Factor Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune System Process Innate Immune Response Response To Tumor Necrosis Factor Cellular Response To Stimulus I-kappaB Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune Response Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Signaling Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Cell Communication Signal Transduction Regulation Of Cellular Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Phosphorylation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Cytokine Production Positive Regulation Of Metabolic Process	Innate Immune Response Immune System Process I-kappaB Kinase/NF-kappaB Signaling Immune Response Defense Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Regulation Of ERBB Signaling Pathway Tumor Necrosis Factor Production Alkanesulfonate Metabolic Process Cell Activation Neuromuscular Process Synaptic Growth At Neuromuscular Junction Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Intracellular Signal Transduction Brain Development Head Development Interferon-alpha Production Collateral Sprouting In Absence Of Injury Regulation Of Immune Response Interleukin-6 Production Activation Of Phospholipase A2 Activity Regulation Of Cell Cycle Regulation Of Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Positive Regulation Of Phospholipase A2 Activity Collateral Sprouting Axon Midline Choice Point Recognition Dendritic Cell Proliferation Central Nervous System Development Response To Cobalamin Response To UV-A Negative Regulation Of Neutrophil Degranulation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Hydrolase Activity Response To Hydroxyisoflavone Regulation Of Neutrophil Degranulation Negative Regulation Of Neutrophil Activation Axon Choice Point Recognition Response To Stimulus Learning Or Memory Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Inflammatory Response Peptidyl-tyrosine Phosphorylation Neurological System Process Positive Regulation Of Cell Cycle Cognition Cell Adhesion
Tagcloud ?		benzene cargo census cleaning conditional crew deck gasoline haematopoietic haenszel hodgkin leukaemia lymphatic malignancies mantel nested operations ors petroleum record referent referents register registry seamen swedish tankers unloading vapours	a4 additive aging amyloid apbb1 aplp1 apolipoprotein c57bl clues dysregulation elusive fe65 hippocampal hypertension hypertensive impairments m1 manifestation maze mint3 mo muscarinic object precursor predisposes secretases signature tauopathy wk
Tagcloud (Difference) ?		benzene cargo census cleaning conditional crew deck gasoline haematopoietic haenszel hodgkin leukaemia lymphatic malignancies mantel nested operations ors petroleum record referent referents register registry seamen swedish tankers unloading vapours	a4 additive aging amyloid apbb1 aplp1 apolipoprotein c57bl clues dysregulation elusive fe65 hippocampal hypertension hypertensive impairments m1 manifestation maze mint3 mo muscarinic object precursor predisposes secretases signature tauopathy wk
Tagcloud (Intersection) ?