VPS11 - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ALG9	ALG9 alpha-1,2-mannosyltransferase	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l)		Congenital disorders of glycosylation (CDG) type I
BCAR1	BCAR1 scaffold protein, Cas family member	Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
BMI1	BMI1 proto-oncogene, polycomb ring finger	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6		Penile cancer
ECPAS	Ecm29 proteasome adaptor and scaffold
EZR	ezrin	Netrin-1 signaling Recycling pathway of L1 Recycling pathway of L1
FUT1	fucosyltransferase 1 (H blood group)	ABO blood group biosynthesis
GGA3	golgi associated, gamma adaptin ear containing, ARF binding protein 3	TBC/RABGAPs MET receptor recycling Amyloid fiber formation
KDM1A	lysine demethylase 1A	HDACs deacetylate histones HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Regulation of PTEN gene transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Factors involved in megakaryocyte development and platelet production
KRTAP10-3	keratin associated protein 10-3	Keratinization
KRTAP10-8	keratin associated protein 10-8	Keratinization
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	Antigen processing: Ubiquitination & Proteasome degradation
LSM1	LSM1 homolog, mRNA degradation associated	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease
MALL	mal, T cell differentiation protein like
MARK3	microtubule affinity regulating kinase 3	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
MON1B	MON1 homolog B, secretory trafficking associated	RAB GEFs exchange GTP for GDP on RABs
MSN	moesin	Recycling pathway of L1 Recycling pathway of L1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
RAB7A	RAB7A, member RAS oncogene family	MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Suppression of autophagy	Guanosine-5'-Diphosphate	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
RDX	radixin	Recycling pathway of L1 Recycling pathway of L1	1D-myo-inositol 1,4,5-trisphosphate
RILP	Rab interacting lysosomal protein	MHC class II antigen presentation
RNF181	ring finger protein 181	E3 ubiquitin ligases ubiquitinate target proteins
RNF26	ring finger protein 26
STX1A	syntaxin 1A	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Insulin processing Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type C (BoNT/C) LGI-ADAM interactions Neurexins and neuroligins GABA synthesis, release, reuptake and degradation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
STX6	syntaxin 6	Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
STX7	syntaxin 7
STX8	syntaxin 8
TFAP2B	transcription factor AP-2 beta	SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors		Char syndrome
TRIM32	tripartite motif containing 32	Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation		Bardet-Biedl syndrome (BBS)
TSG101	tumor susceptibility 101	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
UBE2D2	ubiquitin conjugating enzyme E2 D2	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Antigen processing: Ubiquitination & Proteasome degradation	(R,R)-2,3-Butanediol
UBE2L3	ubiquitin conjugating enzyme E2 L3	Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
UBE2U	ubiquitin conjugating enzyme E2 U	Antigen processing: Ubiquitination & Proteasome degradation
UVRAG	UV radiation resistance associated	Macroautophagy
VPS16	VPS16 core subunit of CORVET and HOPS complexes
VPS18	VPS18 core subunit of CORVET and HOPS complexes
VPS33A	VPS33A core subunit of CORVET and HOPS complexes
VPS45	vacuolar protein sorting 45 homolog	Intra-Golgi traffic Factors involved in megakaryocyte development and platelet production
WNT1	Wnt family member 1	TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Transcriptional regulation of white adipocyte differentiation PCP/CE pathway PCP/CE pathway Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane

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