VPS11 and VPS45

Number of citations of the paper that reports this interaction (PubMedID 14623309)
7

Data Source:
HPRD (in vivo)

		VPS11	VPS45
Description		VPS11 core subunit of CORVET and HOPS complexes	vacuolar protein sorting 45 homolog
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Clathrin-coated Vesicle Endocytic Vesicle HOPS Complex Late Endosome Membrane	Golgi Membrane Cellular_component Golgi Apparatus Synaptic Vesicle Endosome Membrane Integral Component Of Membrane
	Molecular Function	Nucleotide Binding Protein Binding Protein Domain Specific Binding Syntaxin Binding Protein Binding, Bridging Metal Ion Binding	Molecular_function Protein Binding
	Biological Process	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Endosome To Lysosome Transport Regulation Of Protein Stability Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Regulation Of Organelle Assembly Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Early Endosome To Late Endosome Transport	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Blood Coagulation
Pathways			Intra-Golgi traffic Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Body mass index ( 29273807) Coronary artery disease ( 29212778)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Obesity in adult survivors of childhood cancer not exposed to cranial radiation ( 25963547) Schizophrenia ( 25056061 29483656) Uric acid levels ( 21294900)
Interacting Genes		37 interacting genes: ALG9 BCAR1 BMI1 ECPAS EZR FUT1 GGA3 KDM1A KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MALL MARK3 MON1B MSN RAB7A RDX RILP RNF181 RNF26 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2D2 UBE2L3 UBE2U UVRAG VPS16 VPS18 VPS33A VPS45 WNT1	11 interacting genes: BCAR3 CASP8 IGF1R PAX2 PTPN1 RB1CC1 RBSN SNTG1 STX16 VPS11 VPS18
Entrez ID		55823	11311
HPRD ID		12258	10301
Ensembl ID		ENSG00000160695	ENSG00000136631
Uniprot IDs		A0A087WXL6 B7Z879 Q9H270	A0A2R8YE10 B7Z360 B7Z5D4 Q9NRW7
PDB IDs
Enriched GO Terms of Interacting Partners?
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