PVR - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
AP1M2	adaptor related protein complex 1 subunit mu 2	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
CD226	CD226 molecule	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell		Type I diabetes mellitus
CD96	CD96 molecule	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell		C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
DMPK	DM1 protein kinase	Ion homeostasis	3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione	Myotonic dystrophy (DM)
DYNLT1	dynein light chain Tctex-type 1	Neutrophil degranulation
DYNLT3	dynein light chain Tctex-type 3
GMEB2	glucocorticoid modulatory element binding protein 2
KRTAP10-3	keratin associated protein 10-3	Keratinization
KRTAP10-7	keratin associated protein 10-7	Keratinization
KRTAP10-8	keratin associated protein 10-8	Keratinization
KRTAP10-9	keratin associated protein 10-9	Keratinization
NECTIN1	nectin cell adhesion molecule 1	Adherens junctions interactions Nectin/Necl trans heterodimerization		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
NECTIN2	nectin cell adhesion molecule 2	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization
NECTIN3	nectin cell adhesion molecule 3	Adherens junctions interactions Nectin/Necl trans heterodimerization
NOTCH2NLA	notch 2 N-terminal like A
PLA2G3	phospholipase A2 group III	Acyl chain remodelling of PC Acyl chain remodelling of PE Acyl chain remodelling of PG
PLAT	plasminogen activator, tissue type	Signaling by PDGF Dissolution of Fibrin Clot	Urokinase Aminocaproic Acid Ibuprofen Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
PSG11	pregnancy specific beta-1-glycoprotein 11	Cell surface interactions at the vascular wall
PSG9	pregnancy specific beta-1-glycoprotein 9	Cell surface interactions at the vascular wall
PSMD8	proteasome 26S subunit, non-ATPase 8	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK - noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
SLC22A4	solute carrier family 22 member 4	Organic cation transport	L-Carnitine	Crohn's disease
SLC30A2	solute carrier family 30 member 2	Zinc efflux and compartmentalization by the SLC30 family
TIGIT	T cell immunoreceptor with Ig and ITIM domains
VTN	vitronectin	Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade	Abciximab Zinc Copper
WNK1	WNK lysine deficient protein kinase 1	Stimuli-sensing channels		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)

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