PDE4DIP - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	Ethanol oxidation	NADH Fomepizole N-Benzylformamide 4-Iodopyrazole 2'-Monophosphoadenosine 5'-Diphosphoribose Cyclohexanol N-Heptylformamide Glycerin
AEN	apoptosis enhancing nuclease
ANKRD11	ankyrin repeat domain 11
ARNT2	aryl hydrocarbon receptor nuclear translocator 2	PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling
BYSL	bystin like	Major pathway of rRNA processing in the nucleolus and cytosol
C1orf109	chromosome 1 open reading frame 109
CCDC146	coiled-coil domain containing 146
CCDC198	coiled-coil domain containing 198
CDC5L	cell division cycle 5 like	mRNA Splicing - Major Pathway
CDKN1A	cyclin dependent kinase inhibitor 1A	SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint TFAP2 (AP-2) family regulates transcription of cell cycle factors Transcriptional regulation by RUNX2 RUNX3 regulates CDKN1A transcription Transcriptional regulation of granulopoiesis FOXO-mediated transcription of cell cycle genes	Arsenic trioxide	Cervical cancer
CHCHD3	coiled-coil-helix-coiled-coil-helix domain containing 3	Mitochondrial protein import Cristae formation
CHD1L	chromodomain helicase DNA binding protein 1 like	Formation of Incision Complex in GG-NER Dual Incision in GG-NER
EGR2	early growth response 2	Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
EIF4E2	eukaryotic translation initiation factor 4E family member 2	ISG15 antiviral mechanism
FAM161A	FAM161 centrosomal protein A			Retinitis pigmentosa (RP)
FAM74A4	family with sequence similarity 74 member A4
FCHSD2	FCH and double SH3 domains 2
FES	FES proto-oncogene, tyrosine kinase	Signaling by SCF-KIT Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
FHL1	four and a half LIM domains 1			X-linked myopathy with postural muscle atrophy (XMPMA) Reducing body myopathy (RBM) Scapuloperoneal myopathy (SPM) Emery-Dreifuss muscular dystrophy
GADD45G	growth arrest and DNA damage inducible gamma
GBE1	1,4-alpha-glucan branching enzyme 1	Glycogen synthesis Glycogen storage disease type IV (GBE1)		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GFI1B	growth factor independent 1B transcriptional repressor
GNRHR2	gonadotropin releasing hormone receptor 2 (pseudogene)
GOLGA5	golgin A5	Intra-Golgi traffic
GOLGA8EP	golgin A8 family member E, pseudogene
GOLGA8F	golgin A8 family member F
HAUS1	HAUS augmin like complex subunit 1	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
IMMT	inner membrane mitochondrial protein	Cristae formation
ITSN2	intersectin 2	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
KDM1A	lysine demethylase 1A	HDACs deacetylate histones HDMs demethylate histones Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Regulation of PTEN gene transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Factors involved in megakaryocyte development and platelet production
KLC3	kinesin light chain 3	MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
KLC4	kinesin light chain 4	MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
KRAS	KRAS proto-oncogene, GTPase	Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF RUNX3 regulates p14-ARF RAS GTPase cycle mutants Signaling downstream of RAS mutants	[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID FARNESYL DIPHOSPHATE	Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome Pancreatic cancer Gastric cancer Colorectal cancer Non-small cell lung cancer Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Oral cancer Acute myeloid leukemia (AML) Endometrial Cancer Multiple myeloma Squamous cell carcinoma Kaposi's sarcoma Cholangiocarcinoma Thyroid cancer Cervical cancer Hepatocellular carcinoma Ovarian cancer Gallbladder cancer
KRT1	keratin 1	Neutrophil degranulation Keratinization Formation of the cornified envelope	Zinc Copper	Epidermolytic palmoplantar keratoderma (EPPK) Ichthyosis hystrix, Curth-Macklin type Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Striate palmoplantar keratoderma
KRT18	keratin 18	Keratinization Formation of the cornified envelope
KRT31	keratin 31	Keratinization Formation of the cornified envelope
LAMTOR3	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	Macroautophagy mTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1
LENG1	leukocyte receptor cluster member 1
LMO4	LIM domain only 4
MIF4GD	MIF4G domain containing
MTUS2	microtubule associated scaffold protein 2
NAA10	N-alpha-acetyltransferase 10, NatA catalytic subunit
NEFL	neurofilament light	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
NEK2	NIMA related kinase 2	APC-Cdc20 mediated degradation of Nek2A Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE
OSGEP	O-sialoglycoprotein endopeptidase	tRNA modification in the nucleus and cytosol
PDE4D	phosphodiesterase 4D	DARPP-32 events G alpha (s) signalling events	Adenosine monophosphate Caffeine Dyphylline Iloprost Roflumilast Piclamilast Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol 6-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-One 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester (S)-Rolipram Cilomilast (R)-Rolipram 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Crisaborole Ibudilast Tetomilast Apremilast (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-isobutyl-1-methyl-7H-xanthine 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil
PEA15	proliferation and apoptosis adaptor protein 15	RAF-independent MAPK1/3 activation RAF/MAP kinase cascade
PFDN1	prefoldin subunit 1	Prefoldin mediated transfer of substrate to CCT/TriC
PIAS4	protein inhibitor of activated STAT 4	Vitamin D (calciferol) metabolism SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
PPP1R18	protein phosphatase 1 regulatory subunit 18
PRNP	prion protein	NCAM1 interactions Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Tetracycline Copper	Prion diseases; Creutzfeldt-Jacob disease (CJD); Gerstmann-Straussler disease (GSD); Gerstmann-Straussler-Scheinker disease (GSSD); Fatal familial insomnia (FFI)
PRPF31	pre-mRNA processing factor 31	mRNA Splicing - Major Pathway		Retinitis pigmentosa (RP)
RBM8A	RNA binding motif protein 8A	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
RTP5	receptor transporter protein 5 (putative)	Olfactory Signaling Pathway
SCNM1	sodium channel modifier 1
SDCBP	syndecan binding protein	Ephrin signaling Neurofascin interactions Neutrophil degranulation
SH2D4A	SH2 domain containing 4A
SHFL	shiftless antiviral inhibitor of ribosomal frameshifting
SMN1	survival of motor neuron 1, telomeric	snRNP Assembly	Nusinersen	Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
SNCA	synuclein alpha	Amyloid fiber formation	Resveratrol Copper	Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
TEAD4	TEA domain transcription factor 4	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
TFIP11	tuftelin interacting protein 11	mRNA Splicing - Major Pathway
THRB	thyroid hormone receptor beta	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors	Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione Tiratricol GC-24 Eprotirome MB07811 Sobetirome 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE
TK1	thymidine kinase 1	G1/S-Specific Transcription Pyrimidine salvage	Dithioerythritol Thymidine-5'-Triphosphate
TMOD4	tropomodulin 4	Striated Muscle Contraction
TNIK	TRAF2 and NCK interacting kinase	Oxidative Stress Induced Senescence
TRAF4	TNF receptor associated factor 4
UTP14C	UTP14C small subunit processome component	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
VAC14	VAC14 component of PIKFYVE complex	Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
ZBTB38	zinc finger and BTB domain containing 38
ZDHHC17	zinc finger DHHC-type palmitoyltransferase 17
ZFYVE21	zinc finger FYVE-type containing 21
ZNF408	zinc finger protein 408
ZNF512B	zinc finger protein 512B
ZNF581	zinc finger protein 581
ZSCAN26	zinc finger and SCAN domain containing 26

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