MIPOL1 - Wiki-CORONA

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ARNT2	aryl hydrocarbon receptor nuclear translocator 2	PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling
ATP5PO	ATP synthase peripheral stalk subunit OSCP	Formation of ATP by chemiosmotic coupling Cristae formation	Artenimol
BEX2	brain expressed X-linked 2
BYSL	bystin like	Major pathway of rRNA processing in the nucleolus and cytosol
CCDC33	coiled-coil domain containing 33
CCT3	chaperonin containing TCP1 subunit 3	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Phosphoaminophosphonic Acid-Adenylate Ester Artenimol
CDK18	cyclin dependent kinase 18
CKS1B	CDC28 protein kinase regulatory subunit 1B	SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1	Fluoxetine Meta Vanadate
DGCR6	DiGeorge syndrome critical region gene 6
EAF1	ELL associated factor 1	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
EIF4E2	eukaryotic translation initiation factor 4E family member 2	ISG15 antiviral mechanism
ENKD1	enkurin domain containing 1
FAM161A	FAM161 centrosomal protein A			Retinitis pigmentosa (RP)
FBF1	Fas binding factor 1	Anchoring of the basal body to the plasma membrane
HAUS1	HAUS augmin like complex subunit 1	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
MAGEA6	MAGE family member A6
MCM7	minichromosome maintenance complex component 7	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
MFAP1	microfibril associated protein 1	Molecules associated with elastic fibres
MYLIP	myosin regulatory light chain interacting protein	VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation
NEBL	nebulette
PPP1R13B	protein phosphatase 1 regulatory subunit 13B	Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
PRPF31	pre-mRNA processing factor 31	mRNA Splicing - Major Pathway		Retinitis pigmentosa (RP)
RBM41	RNA binding motif protein 41
RCOR3	REST corepressor 3
RNF6	ring finger protein 6	Antigen processing: Ubiquitination & Proteasome degradation
RPL10L	ribosomal protein L10 like	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Anisomycin Puromycin
RTP5	receptor transporter protein 5 (putative)	Olfactory Signaling Pathway
SCNM1	sodium channel modifier 1
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Phenethyl Isothiocyanate
SRPK2	SRSF protein kinase 2		Adenine Purvalanol Phosphoaminophosphonic Acid-Adenylate Ester
SSX3	SSX family member 3
TCHP	trichoplein keratin filament binding
TTC12	tetratricopeptide repeat domain 12
UBE2K	ubiquitin conjugating enzyme E2 K	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
USH1C	USH1 protein network component harmonin			Usher syndrome (US) Deafness, autosomal recessive
UTP25	UTP25 small subunit processor component	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
ZGPAT	zinc finger CCCH-type and G-patch domain containing
ZNF688	zinc finger protein 688	Generic Transcription Pathway

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