| AZI2 |
5-azacytidine induced 2 |
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| BLM |
BLM RecQ like helicase |
- Processive synthesis on the C-strand of the telomere
- SUMOylation of DNA damage response and repair proteins
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Meiotic recombination
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- DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
- Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
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| CABLES1 |
Cdk5 and Abl enzyme substrate 1 |
- Cyclin E associated events during G1/S transition
- Cyclin A:Cdk2-associated events at S phase entry
- Factors involved in megakaryocyte development and platelet production
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| CEP131 |
centrosomal protein 131 |
- Regulation of PLK1 Activity at G2/M Transition
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- AURKA Activation by TPX2
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| CHST9 |
carbohydrate sulfotransferase 9 |
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| DAB2 |
DAB adaptor protein 2 |
- Gap junction degradation
- Formation of annular gap junctions
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
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| DAPK1 |
death associated protein kinase 1 |
- Caspase activation via Dependence Receptors in the absence of ligand
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- 5,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine
- Phosphoaminophosphonic Acid-Adenylate Ester
- 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE
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| EPB41L4A |
erythrocyte membrane protein band 4.1 like 4A |
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| GABARAP |
GABA type A receptor-associated protein |
- Macroautophagy
- TBC/RABGAPs
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| JAG1 |
jagged canonical Notch ligand 1 |
- Activated NOTCH1 Transmits Signal to the Nucleus
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- RUNX3 regulates NOTCH signaling
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- NOTCH4 Activation and Transmission of Signal to the Nucleus
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- Alagille syndrome
- Tetralogy of Fallot
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| RMC1 |
regulator of MON1-CCZ1 |
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| SNX5 |
sorting nexin 5 |
- Golgi Associated Vesicle Biogenesis
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| TBK1 |
TANK binding kinase 1 |
- IRF3 mediated activation of type 1 IFN
- IRF3 mediated activation of type 1 IFN
- Regulation of innate immune responses to cytosolic DNA
- STAT6-mediated induction of chemokines
- IRF3-mediated induction of type I IFN
- Interleukin-37 signaling
- TICAM1-dependent activation of IRF3/IRF7
- TRAF3-dependent IRF activation pathway
- TRAF6 mediated IRF7 activation
- Negative regulators of DDX58/IFIH1 signaling
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
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| UBE2D1 |
ubiquitin conjugating enzyme E2 D1 |
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Inactivation of APC/C via direct inhibition of the APC/C complex
- TICAM1, RIP1-mediated IKK complex recruitment
- APC/C:Cdc20 mediated degradation of Cyclin B
- Autodegradation of Cdh1 by Cdh1:APC/C
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Phosphorylation of the APC/C
- APC-Cdc20 mediated degradation of Nek2A
- Signaling by BMP
- Downstream TCR signaling
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Separation of Sister Chromatids
- Senescence-Associated Secretory Phenotype (SASP)
- FCERI mediated NF-kB activation
- CLEC7A (Dectin-1) signaling
- Ovarian tumor domain proteases
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional Regulation by VENTX
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- Neddylation
- Peroxisomal protein import
- Negative regulators of DDX58/IFIH1 signaling
- IKK complex recruitment mediated by RIP1
- Antigen processing: Ubiquitination & Proteasome degradation
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| UBE2D2 |
ubiquitin conjugating enzyme E2 D2 |
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- TICAM1, RIP1-mediated IKK complex recruitment
- Downstream TCR signaling
- FCERI mediated NF-kB activation
- CLEC7A (Dectin-1) signaling
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- Neddylation
- Peroxisomal protein import
- Negative regulators of DDX58/IFIH1 signaling
- IKK complex recruitment mediated by RIP1
- Antigen processing: Ubiquitination & Proteasome degradation
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| UBE2D3 |
ubiquitin conjugating enzyme E2 D3 |
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- TICAM1, RIP1-mediated IKK complex recruitment
- Signaling by BMP
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- E3 ubiquitin ligases ubiquitinate target proteins
- Neddylation
- Peroxisomal protein import
- Negative regulators of DDX58/IFIH1 signaling
- IKK complex recruitment mediated by RIP1
- Antigen processing: Ubiquitination & Proteasome degradation
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| UBE2D4 |
ubiquitin conjugating enzyme E2 D4 (putative) |
- Antigen processing: Ubiquitination & Proteasome degradation
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| UBE2N |
ubiquitin conjugating enzyme E2 N |
- ISG15 antiviral mechanism
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- Downstream TCR signaling
- FCERI mediated NF-kB activation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- CLEC7A (Dectin-1) signaling
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- Formation of Incision Complex in GG-NER
- G2/M DNA damage checkpoint
- E3 ubiquitin ligases ubiquitinate target proteins
- Interleukin-1 signaling
- IRAK1 recruits IKK complex
- IKK complex recruitment mediated by RIP1
- Aggrephagy
- Aggrephagy
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Antigen processing: Ubiquitination & Proteasome degradation
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| UBE2U |
ubiquitin conjugating enzyme E2 U |
- Antigen processing: Ubiquitination & Proteasome degradation
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| UBE2W |
ubiquitin conjugating enzyme E2 W |
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Antigen processing: Ubiquitination & Proteasome degradation
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